Heat-labile Enterotoxin: Beyond G(m1) Binding

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2011 Nov 10

PMID 22069646

Citations 38

Authors

Benjamin Mudrak

Meta J Kuehn

Affiliations

Soon will be listed here.

Abstract

Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside G(M1), the toxin's host receptor, but interactions with A-type blood sugars and E. coli lipopolysaccharide have also been identified within the past decade. Here, we review the regulation, assembly, and binding properties of the LT B-subunit pentamer and discuss the possible roles of its numerous molecular interactions.

Citing Articles

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Construction of the ETECFinder database for the characterization of enterotoxigenic (ETEC) and revision of the VirulenceFinder web tool at the CGE website.

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Ding J, Wei K, Feng M, Ying S Front Immunol. 2023; 14:1264560.

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