Potential Usefulness of Quinine to Circumvent the Anthracycline Resistance in Clinical Practice

Overview

Journal Br J Cancer

Specialty Oncology

Date 1990 Sep 1

PMID 2206948

Citations 4

Authors

B Chauffert

H Pelletier

C Corda

E Solary

L Bedenne

D Caillot

F Martin

Affiliations

Soon will be listed here.

Abstract

Quinine, the widely used antimalaria agent, was found to increase the cytotoxicity of epideoxorubicin (epiDXR) in resistant DHD/K12 rat colon cancer cells in vitro. Quinine appeared as slightly less effective than quinidine or verapamil for anthracycline potentiation but its weaker cardiotoxicity could counterbalance this disadvantage in vivo. Serum from six patients treated by conventional doses of quinine (25-30 mg kg-1 day-1) was demonstrated to enhance the accumulation of epiDXR in DHD/K12 cells as judged by fluorescence microscopy and HPLC assay (1.6 to 6-fold compared with control serum). In this patients quinine concentrations in serum ranged from 4.4 to 10.1 micrograms ml-1. Our results suggest that quinine could be safely used as anthracycline resistance modifier in clinical practice.

Citing Articles

Biologically active quinoline and quinazoline alkaloids part I.

Shang X, Morris-Natschke S, Liu Y, Guo X, Xu X, Goto M Med Res Rev. 2017; 38(3):775-828.

PMID: 28902434 PMC: 6421866. DOI: 10.1002/med.21466.

Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Wink M, Ashour M, El-Readi M Front Microbiol. 2012; 3:130.

PMID: 22536197 PMC: 3332394. DOI: 10.3389/fmicb.2012.00130.

Phase I study of intravenous PSC-833 and doxorubicin: reversal of multidrug resistance.

Minami H, Ohtsu T, Fujii H, Igarashi T, Itoh K, Aizawa T Jpn J Cancer Res. 2001; 92(2):220-30.

PMID: 11223552 PMC: 5926698. DOI: 10.1111/j.1349-7006.2001.tb01085.x.

Epirubicin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cancer chemotherapy.

Plosker G, Faulds D Drugs. 1993; 45(5):788-856.

PMID: 7686469 DOI: 10.2165/00003495-199345050-00011.

References

Martin F, Knobel S, Martin M, Bordes M . A carcinofetal antigen located on the membrane of cells from rat intestinal carcinoma in culture. Cancer Res. 1975; 35(2):333-6. View

HALL A . The treatment of malaria. Br Med J. 1976; 1(6005):323-8. PMC: 1638678. DOI: 10.1136/bmj.1.6005.323. View

SCHOMERUS M, Spiegelhalder B, Stieren B, Eichelbaum M . Physiological disposition of verapamil in man. Cardiovasc Res. 1976; 10(5):605-12. DOI: 10.1093/cvr/10.5.605. View

Ochs H, Greenblatt D, Woo E . Clinical pharmacokinetics of quinidine. Clin Pharmacokinet. 1980; 5(2):150-68. DOI: 10.2165/00003088-198005020-00003. View

Holford N, Coates P, Guentert T, RIEGELMAN S, Sheiner L . The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships. Br J Clin Pharmacol. 1981; 11(2):187-95. PMC: 1401584. DOI: 10.1111/j.1365-2125.1981.tb01123.x. View

Martin F, Caignard A, Olsson O, Jeannin J, Leclerc A . Tumoricidal effect of macrophages exposed to adriamycin in vivo or in vitro. Cancer Res. 1982; 42(9):3851-7. View

White N, Looareesuwan S, Warrell D, Warrell M, Bunnag D, Harinasuta T . Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med. 1982; 73(4):564-72. DOI: 10.1016/0002-9343(82)90337-0. View

Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y . Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res. 1982; 42(11):4730-3. View

Chauffert B, Martin F, Caignard A, Jeannin J, Leclerc A . Cytofluorescence localization of adriamycin in resistant colon cancer cells. Cancer Chemother Pharmacol. 1984; 13(1):14-8. DOI: 10.1007/BF00401439. View

10.

Tsuruo T, Iida H, Kitatani Y, Yokota K, Tsukagoshi S, Sakurai Y . Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells. Cancer Res. 1984; 44(10):4303-7. View

11.

Boland M, Roper S, Henry J . Complications of quinine poisoning. Lancet. 1985; 1(8425):384-5. DOI: 10.1016/s0140-6736(85)91398-4. View

12.

Benson 3rd A, Trump D, Koeller J, Egorin M, Olman E, Witte R . Phase I study of vinblastine and verapamil given by concurrent iv infusion. Cancer Treat Rep. 1985; 69(7-8):795-9. View

13.

Silamut K, White N, Looareesuwan S, Warrell D . Binding of quinine to plasma proteins in falciparum malaria. Am J Trop Med Hyg. 1985; 34(4):681-6. DOI: 10.4269/ajtmh.1985.34.681. View

14.

Chauffert B, Martin M, Hammann A, Michel M, Martin F . Amiodarone-induced enhancement of doxorubicin and 4'-deoxydoxorubicin cytotoxicity to rat colon cancer cells in vitro and in vivo. Cancer Res. 1986; 46(2):825-30. View

15.

Slater L, Sweet P, Stupecky M, Wetzel M, Gupta S . Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma. Br J Cancer. 1986; 54(2):235-8. PMC: 2001522. DOI: 10.1038/bjc.1986.167. View

16.

Goldstein L, Galski H, Fojo A, Willingham M, Lai S, Gazdar A . Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst. 1989; 81(2):116-24. DOI: 10.1093/jnci/81.2.116. View

17.

Gottesman M, Pastan I . Clinical trials of agents that reverse multidrug-resistance. J Clin Oncol. 1989; 7(4):409-11. DOI: 10.1200/JCO.1989.7.4.409. View

18.

Dalton W, Grogan T, Meltzer P, Scheper R, Durie B, Taylor C . Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol. 1989; 7(4):415-24. DOI: 10.1200/JCO.1989.7.4.415. View

19.

Oliver M, Harrison N, Bishop J, COLE P, Laurent G . A rapid and convenient assay for counting cells cultured in microwell plates: application for assessment of growth factors. J Cell Sci. 1989; 92 ( Pt 3):513-8. DOI: 10.1242/jcs.92.3.513. View