Host Biomarkers of Clinical Relevance in Tuberculosis: Review of Gene and Protein Expression Studies

Overview

Journal Biomarkers

Specialty Biochemistry

Date 2011 Nov 10

PMID 22066602

Citations 13

Authors

Serene H John

John Kenneth

Archana S Gandhe

Affiliations

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Abstract

Context: Identification of clinically relevant biomarkers is required for better diagnosis, prevention and treatment of tuberculosis.

Objective: In this review, potential host biomarkers in blood or blood cells in tuberculosis were identified by a systematic approach.

Methods: A total of 55 articles were selected from PubMed and Google Scholar that analyzed gene and or protein expression in humans in active and or latent TB. Articles were scored according to certain criteria and categorized as strong or weak studies. Biomarkers reported by more than one article or by a single strong article were identified as potential biomarkers.

Results: Six most promising markers (IP-10, IL-6, IL-10, IL-4, FOXP3 and IL-12) were identified based on their presence in both mycobacterial antigen-stimulated and -unstimulated samples.

Conclusions: With this review we hope to provide a reliable guideline for biomarker studies in tuberculosis.

Citing Articles

Cytokine and Chemokine Profiles in Acute Severe Fever with Thrombocytopenia Syndrome and Scrub Typhus in South Korea.

Kwon J, Hong S, Kim J, Cha H, Kim T, Park S Am J Trop Med Hyg. 2023; 109(6):1311-1318.

PMID: 37903435 PMC: 10793061. DOI: 10.4269/ajtmh.23-0146.

Stabilization of Tuberculosis Reporter Enzyme Fluorescence (REFtb) Diagnostic Reagents for Use at the Point of Care.

Lebedev M, Benjamin A, Koster K, Broyles K, Kumar S, Jilka J Diagnostics (Basel). 2022; 12(7).

PMID: 35885648 PMC: 9324015. DOI: 10.3390/diagnostics12071745.

Identification of Potential Biomarkers and Related Transcription Factors in Peripheral Blood of Tuberculosis Patients.

Xie L, Chao X, Teng T, Li Q, Xie J Int J Environ Res Public Health. 2020; 17(19).

PMID: 32987825 PMC: 7579196. DOI: 10.3390/ijerph17196993.

A three-marker protein biosignature distinguishes tuberculosis from other respiratory diseases in Gambian children.

Togun T, Hoggart C, Agbla S, Gomez M, Egere U, Sillah A EBioMedicine. 2020; 58:102909.

PMID: 32711253 PMC: 7381493. DOI: 10.1016/j.ebiom.2020.102909.

Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence.

Sule P, Tilvawala R, Mustapha T, Hassounah H, Noormohamed A, Kundu S J Clin Microbiol. 2019; 57(12).

PMID: 31511338 PMC: 6879286. DOI: 10.1128/JCM.01462-19.