Posttraumatic Mossy Fiber Sprouting is Related to the Degree of Cortical Damage in Three Mouse Strains

Overview

Journal Epilepsy Res

Specialty Neurology

Date 2011 Nov 4

PMID 22047981

Citations 17

Authors

Robert F Hunt

Laura A Haselhorst

Kathleen M Schoch

Eva C Bach

Jennifer Rios-Pilier

Stephen W Scheff

Kathryn E Saatman

Bret N Smith

Affiliations

Soon will be listed here.

Abstract

Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.

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