["The Inflammasomes"]

Overview

Journal Nihon Rinsho Meneki Gakkai Kaishi

Specialty Allergy & Immunology

Date 2011 Nov 2

PMID 22041421

Citations 3

Authors

Junya Masumoto

Affiliations

Soon will be listed here.

Abstract

Inflammation is a host adaptational response to cell injury caused by various exogenous and endogenous stimuli. IL-1β, which is an important proinflammatory cytokine secreted at the site of cellular injury, plays an important role in inflammation. Inflammasome is an intracellular multi-protein complex that mediates caspase-1-dependent processing of IL-1β. In this review, inflammasome function and its dysregulation are discussed in relation to autoinflammatory diseases.

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