High-resolution Manometry: an Atlas of Esophageal Motility Disorders and Findings of GERD Using Esophageal Pressure Topography

Overview

Journal Thorac Surg Clin

Publisher Elsevier

Specialties General Surgery
Pulmonary Medicine

Date 2011 Nov 2

PMID 22040629

Citations 20

Authors

John E Pandolfino

Sabine Roman

Affiliations

Soon will be listed here.

Abstract

High-resolution manometry (HRM) has now become widely available and currently is moving into mainstream clinical practice. This article provides an HRM-related atlas of esophageal motility disorders focused on dysphagia and gastroesophageal reflux disease (GERD). Although there is some overlap between esophageal motor disorders associated with dysphagia and the defects and esophageal motor function that would predispose the patient to more severe GERD, this review is organized to differentiate the distinct pathophysiologic components of the two disease groups. A section on impaired bolus transit is also included to highlight the important aspect of impaired clearance in the pathogenesis of GERD.

Citing Articles

Associations Between Patterns of Esophageal Dysmotility and Extra-Intestinal Features in Patients With Systemic Sclerosis.

Tucker A, Perin J, Volkmann E, Abdi T, Shah A, Pandolfino J Arthritis Care Res (Hoboken). 2022; 75(8):1715-1724.

PMID: 36576023 PMC: 11019887. DOI: 10.1002/acr.25080.

Esophagogastric Junction Outflow Obstruction and Hiatal Hernia: Is Hernia Repair Alone Sufficient?.

DeLong C, Liu A, Taylor M, Lyn-Sue J, Winder J, Pauli E JSLS. 2022; 26(4).

PMID: 36452906 PMC: 9673993. DOI: 10.4293/JSLS.2022.00051.

Preoperative physiological esophageal assessment for anti-reflux surgery: A guide for surgeons on high-resolution manometry and pH testing.

Yodice M, Mignucci A, Shah V, Ashley C, Tadros M World J Gastroenterol. 2021; 27(16):1751-1769.

PMID: 33967555 PMC: 8072189. DOI: 10.3748/wjg.v27.i16.1751.

Impact of Feeding Strategies With Acid Suppression on Esophageal Reflexes in Human Neonates With Gastroesophageal Reflux Disease: A Single-Blinded Randomized Clinical Trial.

Jadcherla S, Hasenstab K, Gulati I, Helmick R, Ipek H, Yildiz V Clin Transl Gastroenterol. 2020; 11(11):e00249.

PMID: 33259163 PMC: 7643906. DOI: 10.14309/ctg.0000000000000249.

Three-dimensional imaging of upper esophageal sphincter resting pressure.

Chitose S, Shin Y, Sato K, Hamakawa S, Fukahori M, Ono T Laryngoscope Investig Otolaryngol. 2020; 4(6):645-652.

PMID: 31890883 PMC: 6929582. DOI: 10.1002/lio2.324.

References

Roman S, Lin Z, Kwiatek M, Pandolfino J, Kahrilas P . Weak peristalsis in esophageal pressure topography: classification and association with Dysphagia. Am J Gastroenterol. 2010; 106(2):349-56. PMC: 3035759. DOI: 10.1038/ajg.2010.384. View

Pandolfino J, El-Serag H, Zhang Q, Shah N, Ghosh S, Kahrilas P . Obesity: a challenge to esophagogastric junction integrity. Gastroenterology. 2006; 130(3):639-49. DOI: 10.1053/j.gastro.2005.12.016. View

Pandolfino J, Leslie E, Luger D, Mitchell B, Kwiatek M, Kahrilas P . The contractile deceleration point: an important physiologic landmark on oesophageal pressure topography. Neurogastroenterol Motil. 2010; 22(4):395-400, e90. PMC: 2883458. DOI: 10.1111/j.1365-2982.2009.01443.x. View

Scherer J, Kwiatek M, Soper N, Pandolfino J, Kahrilas P . Functional esophagogastric junction obstruction with intact peristalsis: a heterogeneous syndrome sometimes akin to achalasia. J Gastrointest Surg. 2009; 13(12):2219-25. PMC: 2892013. DOI: 10.1007/s11605-009-0975-7. View

Pandolfino J, Fox M, Bredenoord A, Kahrilas P . High-resolution manometry in clinical practice: utilizing pressure topography to classify oesophageal motility abnormalities. Neurogastroenterol Motil. 2009; 21(8):796-806. PMC: 2892003. DOI: 10.1111/j.1365-2982.2009.01311.x. View

Roman S, Lin Z, Pandolfino J, Kahrilas P . Distal contraction latency: a measure of propagation velocity optimized for esophageal pressure topography studies. Am J Gastroenterol. 2010; 106(3):443-51. PMC: 3049837. DOI: 10.1038/ajg.2010.414. View

Hill L, Kozarek R, Kraemer S, Aye R, Mercer C, Low D . The gastroesophageal flap valve: in vitro and in vivo observations. Gastrointest Endosc. 1996; 44(5):541-7. DOI: 10.1016/s0016-5107(96)70006-8. View

Sloan S, Rademaker A, Kahrilas P . Determinants of gastroesophageal junction incompetence: hiatal hernia, lower esophageal sphincter, or both?. Ann Intern Med. 1992; 117(12):977-82. DOI: 10.7326/0003-4819-117-12-977. View

Leite L, Johnston B, Barrett J, Castell J, Castell D . Ineffective esophageal motility (IEM): the primary finding in patients with nonspecific esophageal motility disorder. Dig Dis Sci. 1997; 42(9):1859-65. DOI: 10.1023/a:1018802908358. View

10.

Clouse R, Staiano A . Topography of the esophageal peristaltic pressure wave. Am J Physiol. 1991; 261(4 Pt 1):G677-84. DOI: 10.1152/ajpgi.1991.261.4.G677. View

11.

Ghosh S, Pandolfino J, Zhang Q, Jarosz A, Shah N, Kahrilas P . Quantifying esophageal peristalsis with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol. 2006; 290(5):G988-97. DOI: 10.1152/ajpgi.00510.2005. View

12.

Pandolfino J, Shi G, Trueworthy B, Kahrilas P . Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects. Gastroenterology. 2003; 125(4):1018-24. DOI: 10.1016/s0016-5085(03)01210-1. View

13.

Ghosh S, Pandolfino J, Kwiatek M, Kahrilas P . Oesophageal peristaltic transition zone defects: real but few and far between. Neurogastroenterol Motil. 2008; 20(12):1283-90. PMC: 2886597. DOI: 10.1111/j.1365-2982.2008.01169.x. View

14.

Agrawal A, Hila A, Tutuian R, Mainie I, Castell D . Clinical relevance of the nutcracker esophagus: suggested revision of criteria for diagnosis. J Clin Gastroenterol. 2006; 40(6):504-9. DOI: 10.1097/00004836-200607000-00008. View

15.

Pandolfino J, Shi G, Curry J, Joehl R, Brasseur J, Kahrilas P . Esophagogastric junction distensibility: a factor contributing to sphincter incompetence. Am J Physiol Gastrointest Liver Physiol. 2002; 282(6):G1052-8. DOI: 10.1152/ajpgi.00279.2001. View

16.

Benjamin S, Gerhardt D, Castell D . High amplitude, peristaltic esophageal contractions associated with chest pain and/or dysphagia. Gastroenterology. 1979; 77(3):478-83. View

17.

Pratap N, Reddy D . Can achalasia subtyping by high-resolution manometry predict the therapeutic outcome of pneumatic balloon dilatation?: author's reply. J Neurogastroenterol Motil. 2011; 17(2):205. PMC: 3093020. DOI: 10.5056/jnm.2011.17.2.205. View

18.

Pohl D, Ribolsi M, Savarino E, Fruhauf H, Fried M, Castell D . Characteristics of the esophageal low-pressure zone in healthy volunteers and patients with esophageal symptoms: assessment by high-resolution manometry. Am J Gastroenterol. 2008; 103(10):2544-9. DOI: 10.1111/j.1572-0241.2008.02062.x. View

19.

Behar J, Biancani P . Pathogenesis of simultaneous esophageal contractions in patients with motility disorders. Gastroenterology. 1993; 105(1):111-8. DOI: 10.1016/0016-5085(93)90016-6. View

20.

Pandolfino J, Ghosh S, Zhang Q, Jarosz A, Shah N, Kahrilas P . Quantifying EGJ morphology and relaxation with high-resolution manometry: a study of 75 asymptomatic volunteers. Am J Physiol Gastrointest Liver Physiol. 2006; 290(5):G1033-40. DOI: 10.1152/ajpgi.00444.2005. View