Acute Lymphoblastic Leukemia and Developmental Biology: a Crucial Interrelationship

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2011 Oct 28

PMID 22031225

Citations 12

Authors

Elena Campos-Sanchez

Amparo Toboso-Navasa

Isabel Romero-Camarero

Marcos Barajas-Diego

Isidro Sanchez-Garcia

Cesar Cobaleda

Affiliations

Soon will be listed here.

Abstract

The latest scientific findings in the field of cancer research are redefining our understanding of the molecular and cellular basis of the disease, moving the emphasis toward the study of the mechanisms underlying the alteration of the normal processes of cellular differentiation. The concepts best exemplifying this new vision are those of cancer stem cells and tumoral reprogramming. The study of the biology of acute lymphoblastic leukemias (ALLs) has provided seminal experimental evidence supporting these new points of view. Furthermore, in the case of B cells, it has been shown that all the stages of their normal development show a tremendous degree of plasticity, allowing them to be reprogrammed to other cellular types, either normal or leukemic. Here we revise the most recent discoveries in the fields of B-cell developmental plasticity and B-ALL research and discuss their interrelationships and their implications for our understanding of the biology of the disease.

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