Interleukin-6 Plasmatic Levels in Patients with Head Trauma and Intracerebral Hemorrhage

Overview

Journal Asian J Neurosurg

Specialty Neurology

Date 2011 Oct 27

PMID 22028746

Citations 12

Authors

Alessandra Armstrong Antunes

Vanessa Santos Sotomaior

Keyth Suga Sakamoto

Cyro Pereira de Camargo Neto

Carolina Martins

Luiz Roberto Aguiar

Affiliations

Soon will be listed here.

Abstract

The exact role of inflammatory response in hemorrhagic contusions is not fully characterized. The present study quantified IL-6 plasmatic levels in patients with closed head trauma and hemorrhagic contusions during the first 6 to 12 hours postrauma. The association between the plasmatic IL-6 levels, severity of trauma according to the Glasgow Coma Scale, volume of intracerebral hemorrhage and patient's clinical evolution were investigated. Although inflammation is a multifactorial process, a strong correlation between IL-6 levels, volume of traumatic hemorrhage and in-hospital evolution could be observed. A correlation between the IL-6 levels quantified 6 hours postrauma and progression of lesion volume between admission and 12 hours postrauma is suggested. The present study reinforces the importance of IL-6 in influencing the clinical conditions of a patient with cerebral injuries, particularly hemorrhagic contusions.

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