New Directions in Migraine

Overview

Journal BMC Med

Publisher Biomed Central

Specialty General Medicine

Date 2011 Oct 27

PMID 22027350

Citations 14

Authors

Greg A Weir

M Zameel Cader

Affiliations

Soon will be listed here.

Abstract

Migraine is a highly prevalent neurological disorder imparting a major burden on health care around the world. The primary pathology may be a state of hyperresponsiveness of the nervous system, but the molecular mechanisms are yet to be fully elucidated. We could now be at a watershed moment in this respect, as the genetic loci associated with typical forms of migraine are being revealed. The genetic discoveries are the latest step in the evolution of our understanding of migraine, which was initially considered a cerebrovascular condition, then a neuroinflammatory process and now primarily a neurogenic disorder. Indeed, the genetic findings, which have revealed ion channels and transporter mutations as causative of migraine, are a powerful argument for the neurogenic basis of migraine. Modulations of ion channels leading to amelioration of the migraine 'hyperresponsive' brain represent attractive targets for drug discovery. There lies ahead an exciting and rapidly progressing phase of migraine translational research, and in this review we highlight recent genetic findings and consider how these may affect the future of migraine neurobiology and therapy.

Citing Articles

The Proteomic Analysis of Chronic Migraine Exosomes Reveals Disease Patterns and Potential Biomarkers.

Zhang W, Wan F, Duan L, Tao W, Wang J, Huang L Mol Neurobiol. 2024; 62(2):2070-2085.

PMID: 39066974 DOI: 10.1007/s12035-024-04389-w.

Glia Signaling and Brain Microenvironment in Migraine.

Amani H, Khaboushan A, Terwindt G, Tafakhori A Mol Neurobiol. 2023; 60(7):3911-3934.

PMID: 36995514 DOI: 10.1007/s12035-023-03300-3.

Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain.

Tajti J, Szok D, Csati A, Szabo A, Tanaka M, Vecsei L Int J Mol Sci. 2023; 24(4).

PMID: 36835524 PMC: 9959352. DOI: 10.3390/ijms24044114.

Predicting response to tVNS in patients with migraine using functional MRI: A voxels-based machine learning analysis.

Fu C, Zhang Y, Ye Y, Hou X, Wen Z, Yan Z Front Neurosci. 2022; 16:937453.

PMID: 35992927 PMC: 9388938. DOI: 10.3389/fnins.2022.937453.

Glia and Orofacial Pain: Progress and Future Directions.

Ye Y, Salvo E, Romero-Reyes M, Akerman S, Shimizu E, Kobayashi Y Int J Mol Sci. 2021; 22(10).

PMID: 34069553 PMC: 8160907. DOI: 10.3390/ijms22105345.

References

Anttila V, Stefansson H, Kallela M, Todt U, Terwindt G, Calafato M . Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet. 2010; 42(10):869-73. PMC: 2948563. DOI: 10.1038/ng.652. View

Ophoff R, Terwindt G, Vergouwe M, van Eijk R, Oefner P, Hoffman S . Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 1996; 87(3):543-52. DOI: 10.1016/s0092-8674(00)81373-2. View

Tottene A, Fellin T, Pagnutti S, Luvisetto S, Striessnig J, Fletcher C . Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. Proc Natl Acad Sci U S A. 2002; 99(20):13284-9. PMC: 130625. DOI: 10.1073/pnas.192242399. View

Chae Y, Zhang J, Au P, Sabbadini M, Xie G, Yost C . Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK. Anesthesiology. 2010; 113(6):1326-37. PMC: 3010361. DOI: 10.1097/ALN.0b013e3181f90ca5. View

Charles A . Does cortical spreading depression initiate a migraine attack? Maybe not . . . Headache. 2010; 50(4):731-3. DOI: 10.1111/j.1526-4610.2010.01646.x. View

Suzuki M, Van Paesschen W, Stalmans I, Horita S, Yamada H, Bergmans B . Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine. Proc Natl Acad Sci U S A. 2010; 107(36):15963-8. PMC: 2936614. DOI: 10.1073/pnas.1008705107. View

Kahlig K, Rhodes T, Pusch M, Freilinger T, Pereira-Monteiro J, Ferrari M . Divergent sodium channel defects in familial hemiplegic migraine. Proc Natl Acad Sci U S A. 2008; 105(28):9799-804. PMC: 2474506. DOI: 10.1073/pnas.0711717105. View

Nedergaard M, Cooper A, Goldman S . Gap junctions are required for the propagation of spreading depression. J Neurobiol. 1995; 28(4):433-44. DOI: 10.1002/neu.480280404. View

Lafreniere R, Cader M, Poulin J, Andres-Enguix I, Simoneau M, Gupta N . A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nat Med. 2010; 16(10):1157-60. DOI: 10.1038/nm.2216. View

10.

Ho T, Ferrari M, Dodick D, Galet V, Kost J, Fan X . Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet. 2008; 372(9656):2115-23. DOI: 10.1016/S0140-6736(08)61626-8. View

11.

Huang D, Yu B, Fan Q . Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia. Neurosci Bull. 2008; 24(3):166-72. PMC: 5552547. DOI: 10.1007/s12264-008-0225-0. View

12.

Biondi D . Is migraine a neuropathic pain syndrome?. Curr Pain Headache Rep. 2008; 10(3):167-78. DOI: 10.1007/s11916-006-0042-y. View

13.

Ketter T, Manji H, Post R . Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders. J Clin Psychopharmacol. 2003; 23(5):484-95. DOI: 10.1097/01.jcp.0000088915.02635.e8. View

14.

Goadsby P, Edvinsson L, Ekman R . Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990; 28(2):183-7. DOI: 10.1002/ana.410280213. View

15.

Kearney J, Plummer N, Smith M, Kapur J, Cummins T, Waxman S . A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities. Neuroscience. 2001; 102(2):307-17. DOI: 10.1016/s0306-4522(00)00479-6. View

16.

Durham P, Vause C . Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine. CNS Drugs. 2010; 24(7):539-48. PMC: 3138175. DOI: 10.2165/11534920-000000000-00000. View

17.

De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L . Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet. 2003; 33(2):192-6. DOI: 10.1038/ng1081. View

18.

Benarroch E . Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system. Mayo Clin Proc. 2005; 80(10):1326-38. DOI: 10.4065/80.10.1326. View

19.

Shank R, GARDOCKI J, Streeter A, Maryanoff B . An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia. 2000; 41(S1):3-9. View

20.

Xie Y . Glial involvement in trigeminal central sensitization. Acta Pharmacol Sin. 2008; 29(6):641-5. DOI: 10.1111/j.1745-7254.2008.00801.x. View