Gold Nanocages As Contrast Agents for Photoacoustic Imaging

Overview

Journal Contrast Media Mol Imaging

Specialty Radiology

Date 2011 Oct 26

PMID 22025337

Citations 30

Authors

Weiyang Li

Paige K Brown

Lihong V Wang

Younan Xia

Affiliations

Soon will be listed here.

Abstract

Gold nanoparticles with tunable absorption and scattering properties have been developed as contrast agents for various optical imaging techniques. As a hybrid modality that combines the merits of both optical and ultrasonic imaging, photoacoustic (PA) imaging also benefits from the use of these nanoparticles to greatly enhance the contrast for visualization of structures and biomarkers in biological tissues. Gold nanocages characterized by hollow interiors, ultrathin and porous walls are of particular interest for in vivo PA imaging because of their compact sizes, bio-inertness and well-defined surface chemistry, as well as their strong and highly wavelength-tunable optical absorption in the near-infrared (NIR) optical window of soft tissues. This review discusses the application of gold nanocages as a new class of contrast agents for PA imaging in the context of cancer diagnosis.

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References

Krag D, Weaver D, Alex J, Fairbank J . Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol. 1993; 2(6):335-9; discussion 340. DOI: 10.1016/0960-7404(93)90064-6. View

Maslov K, Stoica G, Wang L . In vivo dark-field reflection-mode photoacoustic microscopy. Opt Lett. 2005; 30(6):625-7. DOI: 10.1364/ol.30.000625. View

Denk W, Strickler J, Webb W . Two-photon laser scanning fluorescence microscopy. Science. 1990; 248(4951):73-6. DOI: 10.1126/science.2321027. View

Kruger R, Reinecke D, KRUGER G . Thermoacoustic computed tomography--technical considerations. Med Phys. 1999; 26(9):1832-7. DOI: 10.1118/1.598688. View

Wang L . Multiscale photoacoustic microscopy and computed tomography. Nat Photonics. 2010; 3(9):503-509. PMC: 2802217. DOI: 10.1038/nphoton.2009.157. View

Morton D, Wen D, Wong J, Economou J, Cagle L, Storm F . Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992; 127(4):392-9. DOI: 10.1001/archsurg.1992.01420040034005. View

Wang X, Pang Y, Ku G, Xie X, Stoica G, Wang L . Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain. Nat Biotechnol. 2003; 21(7):803-6. DOI: 10.1038/nbt839. View

Tanis P, Nieweg O, Valdes Olmos R, Rutgers E, Kroon B . History of sentinel node and validation of the technique. Breast Cancer Res. 2001; 3(2):109-12. PMC: 139441. DOI: 10.1186/bcr281. View

Chen J, McLellan J, Siekkinen A, Xiong Y, Li Z, Xia Y . Facile synthesis of gold-silver nanocages with controllable pores on the surface. J Am Chem Soc. 2006; 128(46):14776-7. PMC: 2532083. DOI: 10.1021/ja066023g. View

10.

Kim C, Cho E, Chen J, Song K, Au L, Favazza C . In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages. ACS Nano. 2010; 4(8):4559-64. PMC: 3065066. DOI: 10.1021/nn100736c. View

11.

Zhang H, Maslov K, Stoica G, Wang L . Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat Biotechnol. 2006; 24(7):848-51. DOI: 10.1038/nbt1220. View

12.

Nakajima M, Takeda M, Kobayashi M, Suzuki S, Ohuchi N . Nano-sized fluorescent particles as new tracers for sentinel node detection: experimental model for decision of appropriate size and wavelength. Cancer Sci. 2005; 96(6):353-6. PMC: 11159817. DOI: 10.1111/j.1349-7006.2005.00053.x. View

13.

Torchia M, Nason R, DANZINGER R, Lewis J, Thliveris J . Interstitial MR lymphangiography for the detection of sentinel lymph nodes. J Surg Oncol. 2001; 78(3):151-6; discussion 157. DOI: 10.1002/jso.1139. View

14.

Siekkinen A, McLellan J, Chen J, Xia Y . Rapid synthesis of small silver nanocubes by mediating polyol reduction with a trace amount of sodium sulfide or sodium hydrosulfide. Chem Phys Lett. 2008; 432(4-6):491-496. PMC: 2390781. DOI: 10.1016/j.cplett.2006.10.095. View

15.

Song K, Wang L . Deep reflection-mode photoacoustic imaging of biological tissue. J Biomed Opt. 2008; 12(6):060503. DOI: 10.1117/1.2818045. View

16.

Kim C, Favazza C, Wang L . In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. Chem Rev. 2010; 110(5):2756-82. PMC: 2872199. DOI: 10.1021/cr900266s. View

17.

Michel S, Keller T, Frohlich J, Fink D, Caduff R, Seifert B . Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement. Radiology. 2002; 225(2):527-36. DOI: 10.1148/radiol.2252011605. View

18.

Weissleder R . A clearer vision for in vivo imaging. Nat Biotechnol. 2001; 19(4):316-7. DOI: 10.1038/86684. View

19.

Skrabalak S, Chen J, Au L, Lu X, Li X, Xia Y . Gold Nanocages for Biomedical Applications. Adv Mater. 2008; 19(20):3177-3184. PMC: 2480527. DOI: 10.1002/adma.200701972. View

20.

Hoelen C, de Mul F, Pongers R, Dekker A . Three-dimensional photoacoustic imaging of blood vessels in tissue. Opt Lett. 2007; 23(8):648-50. DOI: 10.1364/ol.23.000648. View