Subjective Social Status Predicts in Vivo Responsiveness of β-adrenergic Receptors

Overview

Journal Health Psychol

Specialty Public Health

Date 2011 Oct 26

PMID 22023437

Citations 16

Authors

Frank Euteneuer

Paul J Mills

Winfried Rief

Michael G Ziegler

Joel E Dimsdale

Affiliations

Soon will be listed here.

Abstract

Objective: Several poor health outcomes, including cardiovascular risk, have been associated with both subjective social status (SSS) and sympathetic overactivity. Because prolonged sympathetic overactivation down regulates beta adrenergic receptor (β-AR) function, reduced β-AR responsiveness is considered an indicator of sympathetic overactivity and a cardiovascular risk factor. Though prior research has focused on objective social status and β-AR function, no studies have examined the association between SSS and β-AR function. We aimed to learn whether SSS predicts the in vivo responsiveness of β-ARs.

Methods: We assessed the chronotropic 25 dose (CD25), an in vivo marker of β-AR responsiveness, in 94 healthy participants. The MacArthur scales of subjective social status were used to assess SSS in the U.S.A. (SSS-USA) and in the local community (SSS-C). Objective social status was analyzed by calculating the Hollingshead two-factor index.

Results: β-AR responsiveness was reduced (as indicated by higher CD25 values) in participants with lower SSS-USA (p = .007) and lower SSS-C (p < .001). The relationship between CD25 and SSS was particularly robust with respect to SSS-C. Hierarchical regression analyses revealed that SSS-C remained a significant predictor of CD25 (p < .001) and accounted for 14% of the total variance (32%) in CD25 after adjusting for sociodemographic variables (age, ethnicity, gender), health factors (exercise, smoking status, body mass index) and objective social status.

Conclusion: Our results indicate that β-AR function may be an important component of the link between SSS and health.

Citing Articles

A pilot cross-sectional investigation of chronic shame as a mediator of the relationship between subjective social status and self-rated health among middle-aged adults.

McGarity-Shipley E, Lee E, Pyke K Health Psychol Behav Med. 2023; 11(1):2268697.

PMID: 37842010 PMC: 10569351. DOI: 10.1080/21642850.2023.2268697.

Subjective Social Status, Area Deprivation, and Gender Differences in Health among Chinese Older People.

Chen X, Woo J, Yu R, Chung G, Yao W, Yeoh E Int J Environ Res Public Health. 2022; 19(16).

PMID: 36011511 PMC: 9408352. DOI: 10.3390/ijerph19169857.

Association of Subjective Social Status With Life's Simple 7s Cardiovascular Health Index Among Hispanic/Latino People: Results From the HCHS/SOL.

Piedra L, Andrade F, Hernandez R, Perreira K, Gallo L, Gonzalez H J Am Heart Assoc. 2021; 10(16):e012704.

PMID: 34378404 PMC: 8475025. DOI: 10.1161/JAHA.119.012704.

Socioeconomic position over the life-course and subjective social status in relation to nutritional status and mental health among Guatemalan adults.

Varghese J, Hall R, DiGirolamo A, Martorell R, Ramirez-Zea M, Stein A SSM Popul Health. 2021; 15:100880.

PMID: 34377763 PMC: 8327130. DOI: 10.1016/j.ssmph.2021.100880.

Subjective Social Status and Cardiometabolic Risk Markers by Intersectionality of Race/Ethnicity and Sex Among U.S. Young Adults.

McClain A, Gallo L, Mattei J Ann Behav Med. 2021; 56(5):442-460.

PMID: 33942845 PMC: 9116590. DOI: 10.1093/abm/kaab025.

References

Clark A, DesMeules M, Luo W, Duncan A, Wielgosz A . Socioeconomic status and cardiovascular disease: risks and implications for care. Nat Rev Cardiol. 2009; 6(11):712-22. DOI: 10.1038/nrcardio.2009.163. View

Leenen F . Cardiovascular consequences of sympathetic hyperactivity. Can J Cardiol. 1999; 15 Suppl A:2A-7A. View

Janicki-Deverts D, Cohen S, Adler N, Schwartz J, Matthews K, Seeman T . Socioeconomic status is related to urinary catecholamines in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Psychosom Med. 2007; 69(6):514-20. DOI: 10.1097/PSY.0b013e3180f60645. View

Bao X, Mills P, Rana B, Dimsdale J, Schork N, Smith D . Interactive effects of common beta2-adrenoceptor haplotypes and age on susceptibility to hypertension and receptor function. Hypertension. 2005; 46(2):301-7. DOI: 10.1161/01.HYP.0000175842.19266.95. View

Adler N, Epel E, Castellazzo G, Ickovics J . Relationship of subjective and objective social status with psychological and physiological functioning: preliminary data in healthy white women. Health Psychol. 2000; 19(6):586-92. DOI: 10.1037//0278-6133.19.6.586. View

Cleaveland C, Rangno R, SHAND D . A standardized isoproterenol sensitivity test. The effects of sinus arrhythmia, atropine, and propranolol. Arch Intern Med. 1972; 130(1):47-52. DOI: 10.1001/archinte.130.1.47. View

Ostrove J, Adler N, Kuppermann M, Washington A . Objective and subjective assessments of socioeconomic status and their relationship to self-rated health in an ethnically diverse sample of pregnant women. Health Psychol. 2000; 19(6):613-8. DOI: 10.1037//0278-6133.19.6.613. View

Remme W . The sympathetic nervous system and ischaemic heart disease. Eur Heart J. 1998; 19 Suppl F:F62-71. View

Ebstein R, Stessman J, Eliakim R, Menczel J . The effect of age on beta-adrenergic function in man: a review. Isr J Med Sci. 1985; 21(3):302-11. View

10.

Mills P, Dimsdale J . The promise of adrenergic receptor studies in psychophysiologic research II: Applications, limitations, and progress. Psychosom Med. 1993; 55(5):448-57. DOI: 10.1097/00006842-199309000-00008. View

11.

Palatini P . Sympathetic overactivity in hypertension: a risk factor for cardiovascular disease. Curr Hypertens Rep. 2001; 3 Suppl 1:S3-9. DOI: 10.1007/s11906-001-0065-z. View

12.

Ghaed S, Gallo L . Subjective social status, objective socioeconomic status, and cardiovascular risk in women. Health Psychol. 2007; 26(6):668-74. DOI: 10.1037/0278-6133.26.6.668. View

13.

Mazzola-Pomietto P, Azorin J, Tramoni V, Jeanningros R . Relation between lymphocyte beta-adrenergic responsivity and the severity of depressive disorders. Biol Psychiatry. 1994; 35(12):920-5. DOI: 10.1016/0006-3223(94)91238-6. View

14.

Cherkas L, Aviv A, Valdes A, Hunkin J, Gardner J, Surdulescu G . The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell. 2006; 5(5):361-5. DOI: 10.1111/j.1474-9726.2006.00222.x. View

15.

Wilkinson R . Health, hierarchy, and social anxiety. Ann N Y Acad Sci. 2000; 896:48-63. DOI: 10.1111/j.1749-6632.1999.tb08104.x. View

16.

Dimsdale J, Mills P, Patterson T, Ziegler M, Dillon E . Effects of chronic stress on beta-adrenergic receptors in the homeless. Psychosom Med. 1994; 56(4):290-5. DOI: 10.1097/00006842-199407000-00003. View

17.

Cooper D, Milic M, Mills P, Bardwell W, Ziegler M, Dimsdale J . Endothelial function: the impact of objective and subjective socioeconomic status on flow-mediated dilation. Ann Behav Med. 2010; 39(3):222-31. PMC: 2908439. DOI: 10.1007/s12160-010-9181-9. View

18.

Wright C, Steptoe A . Subjective socioeconomic position, gender and cortisol responses to waking in an elderly population. Psychoneuroendocrinology. 2005; 30(6):582-90. DOI: 10.1016/j.psyneuen.2005.01.007. View

19.

Goodman E, Adler N, Kawachi I, Frazier A, Huang B, Colditz G . Adolescents' perceptions of social status: development and evaluation of a new indicator. Pediatrics. 2001; 108(2):E31. DOI: 10.1542/peds.108.2.e31. View

20.

Singh-Manoux A, Marmot M, Adler N . Does subjective social status predict health and change in health status better than objective status?. Psychosom Med. 2005; 67(6):855-61. DOI: 10.1097/01.psy.0000188434.52941.a0. View