Combined Effects of P-coumaric Acid and Naringenin Against Doxorubicin-induced Cardiotoxicity in Rats

Overview

Journal Pharmacognosy Res

Date 2011 Oct 25

PMID 22022172

Citations 7

Authors

Shruti S Shiromwar

Vijay R Chidrawar

Affiliations

Soon will be listed here.

Abstract

Background: Doxorubicin (DOX) is the most active cytotoxic agents having efficacy in malignancies either alone or combined with other cytocidal agents. The clinical usefulness of the anthracycline drug has been precluded by cardiac toxicity. Many therapeutic interventions have been attempted to improve the therapeutic benefits of the drug. This study is based on the possible protective effects of combination of p-coumaric acid (PC) and naringenin (NR) on DOX induced cardiac toxicity in male Swiss albino rats.

Methods: Total nine groups of Swiss albino rats were used, Group I (vehicle control) receive saline solution daily and Group II (disease control) receive saline solution daily up to 29(th) day and at 30(th) day a single dose of DOX (15 mg/kg i.p.) is given. PC alone (100 mg/kg/day p.o.) and (200 mg/kg/day p.o.) also NR alone (15 mg/kg/day) orally administer for 30 days. Similarly a standard drug Vit. E (100 mg/kg/day) administers alone for 30 days. Group PC/DOX and PC and NR/DOX receive PC (200 mg/kg/day) and combine PC (200 mg/kg/day).

Results: Doxorubicin induced marked biochemical alterations characteristic of cardiac toxicity including increase in MDA level and decrease SOD, CAT & GSH level but prior administration of combination of PC & NR ahead of doxorubicin challenge ameliorated all these biochemical markers.

Conclusion: The study proves the beneficial effects of combination of PC and NR in protecting animal against DOX induced cardiotoxicity.

Citing Articles

P-coumaric Acid: Advances in Pharmacological Research Based on Oxidative Stress.

Chen F, Zhang X, Wang J, Wang F, Mao J Curr Top Med Chem. 2024; 24(5):416-436.

PMID: 38279744 DOI: 10.2174/0115680266276823231230183519.

The Role of Flavonoids as a Cardioprotective Strategy against Doxorubicin-Induced Cardiotoxicity: A Review.

Syahputra R, Harahap U, Dalimunthe A, Nasution M, Satria D Molecules. 2022; 27(4).

PMID: 35209107 PMC: 8878416. DOI: 10.3390/molecules27041320.

Rapid Quantitative Analysis of Naringenin in the Fruit Bodies of by Two-phase Acid Hydrolysis Followed by Reversed Phase-high Performance Liquid Chromatography-ultra Violet.

Guohua X, Pan R, Bao R, Ge Y, Zhou C, Shen Y Pharmacogn Mag. 2017; 13(52):659-662.

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Protective effect of -coumaric acid against doxorubicin induced toxicity in H9c2 cardiomyoblast cell lines.

Chacko S, Nevin K, Dhanyakrishnan R, Prakash Kumar B Toxicol Rep. 2017; 2:1213-1221.

PMID: 28962464 PMC: 5598262. DOI: 10.1016/j.toxrep.2015.08.002.

Potential Roles of L. Leaf Extract in Reducing Doxorubicin Acute Hepatic, Cardiac and Renal Toxicities in Rats.

Djabir Y, Aryadi Arsyad M, Sartini S, Lallo S Pharmacognosy Res. 2017; 9(2):168-173.

PMID: 28539741 PMC: 5424558. DOI: 10.4103/pr.pr_129_16.

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