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The Devil is in the Methods: Lineage Tracing, Functional Screens and Sequencing, Hormones, Tumour-stroma Interactions, and Expansion of Human Breast Tumours As Xenografts

Overview
Specialty Oncology
Date 2011 Oct 25
PMID 22017807
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Abstract

The meeting of the European Network for Breast Development and Cancer (ENBDC) on 'Methods in Mammary Gland Development and Cancer' has become an annual international rendezvous for scientists with interests in the normal and neoplastic breast. The third meeting in this series, held in April-May 2011 in Weggis, Switzerland, focussed on functional screens and sequencing, hormones, lineage tracing, tumor-stroma interactions and the expansion of human breast tumours as xenografts.

References
1.
Varela I, Klijn C, Stephens P, Mudie L, Stebbings L, Galappaththige D . Somatic structural rearrangements in genetically engineered mouse mammary tumors. Genome Biol. 2010; 11(10):R100. PMC: 3218656. DOI: 10.1186/gb-2010-11-10-r100. View

2.
Yalcin-Ozuysal O, Fiche M, Guitierrez M, Wagner K, Raffoul W, Brisken C . Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates. Cell Death Differ. 2010; 17(10):1600-12. DOI: 10.1038/cdd.2010.37. View

3.
Mendes-Pereira A, Sims D, Dexter T, Fenwick K, Assiotis I, Kozarewa I . Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen. Proc Natl Acad Sci U S A. 2011; 109(8):2730-5. PMC: 3286962. DOI: 10.1073/pnas.1018872108. View

4.
Loveday C, Turnbull C, Ramsay E, Hughes D, Ruark E, Frankum J . Germline mutations in RAD51D confer susceptibility to ovarian cancer. Nat Genet. 2011; 43(9):879-882. PMC: 4845885. DOI: 10.1038/ng.893. View

5.
Brough R, Frankum J, Sims D, Mackay A, Mendes-Pereira A, Bajrami I . Functional viability profiles of breast cancer. Cancer Discov. 2011; 1(3):260-73. PMC: 3188379. DOI: 10.1158/2159-8290.CD-11-0107. View