Use of Mobile Phones and Risk of Brain Tumours: Update of Danish Cohort Study

Overview

Journal BMJ

Specialty General Medicine

Date 2011 Oct 22

PMID 22016439

Citations 41

Authors

Patrizia Frei

Aslak H Poulsen

Christoffer Johansen

Jorgen H Olsen

Marianne Steding-Jessen

Joachim Schuz

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the risk of tumours in the central nervous system among Danish mobile phone subscribers.

Design: Nationwide cohort study.

Setting: Denmark.

Participants: All Danes aged ≥ 30 and born in Denmark after 1925, subdivided into subscribers and non-subscribers of mobile phones before 1995.

Main Outcome Measures: Risk of tumours of the central nervous system, identified from the complete Danish Cancer Register. Sex specific incidence rate ratios estimated with log linear Poisson regression models adjusted for age, calendar period, education, and disposable income.

Results: 358,403 subscription holders accrued 3.8 million person years. In the follow-up period 1990-2007, there were 10,729 cases of tumours of the central nervous system. The risk of such tumours was close to unity for both men and women. When restricted to individuals with the longest mobile phone use--that is, ≥ 13 years of subscription--the incidence rate ratio was 1.03 (95% confidence interval 0.83 to 1.27) in men and 0.91 (0.41 to 2.04) in women. Among those with subscriptions of ≥ 10 years, ratios were 1.04 (0.85 to 1.26) in men and 1.04 (0.56 to 1.95) in women for glioma and 0.90 (0.57 to 1.42) in men and 0.93 (0.46 to 1.87) in women for meningioma. There was no indication of dose-response relation either by years since first subscription for a mobile phone or by anatomical location of the tumour--that is, in regions of the brain closest to where the handset is usually held to the head.

Conclusions: In this update of a large nationwide cohort study of mobile phone use, there were no increased risks of tumours of the central nervous system, providing little evidence for a causal association.

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References

Neubauer G, Cecil S, Giczi W, Petric B, Preiner P, Frohlich J . The association between exposure determined by radiofrequency personal exposimeters and human exposure: a simulation study. Bioelectromagnetics. 2010; 31(7):535-45. DOI: 10.1002/bem.20587. View

Hardell L, Carlberg M, Hansson Mild K . Mobile phone use and the risk for malignant brain tumors: a case-control study on deceased cases and controls. Neuroepidemiology. 2010; 35(2):109-14. DOI: 10.1159/000311044. View

Storm H, Michelsen E, Clemmensen I, Pihl J . The Danish Cancer Registry--history, content, quality and use. Dan Med Bull. 1997; 44(5):535-9. View

Dalton S, Steding-Jessen M, Gislum M, Frederiksen K, Engholm G, Schuz J . Social inequality and incidence of and survival from cancer in a population-based study in Denmark, 1994-2003: Background, aims, material and methods. Eur J Cancer. 2008; 44(14):1938-49. DOI: 10.1016/j.ejca.2008.06.010. View

Deltour I, Johansen C, Auvinen A, Feychting M, Klaeboe L, Schuz J . Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974-2003. J Natl Cancer Inst. 2009; 101(24):1721-4. DOI: 10.1093/jnci/djp415. View

Cardis E, Deltour I, Mann S, Moissonnier M, Taki M, Varsier N . Distribution of RF energy emitted by mobile phones in anatomical structures of the brain. Phys Med Biol. 2008; 53(11):2771-83. DOI: 10.1088/0031-9155/53/11/001. View

Inskip P, Hoover R, Devesa S . Brain cancer incidence trends in relation to cellular telephone use in the United States. Neuro Oncol. 2010; 12(11):1147-51. PMC: 3098028. DOI: 10.1093/neuonc/noq077. View

Vrijheid M, Deltour I, Krewski D, Sanchez M, Cardis E . The effects of recall errors and of selection bias in epidemiologic studies of mobile phone use and cancer risk. J Expo Sci Environ Epidemiol. 2006; 16(4):371-84. DOI: 10.1038/sj.jes.7500509. View

. Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study. Int J Epidemiol. 2010; 39(3):675-94. DOI: 10.1093/ije/dyq079. View

10.

Schuz J, Jacobsen R, Olsen J, Boice Jr J, McLaughlin J, Johansen C . Cellular telephone use and cancer risk: update of a nationwide Danish cohort. J Natl Cancer Inst. 2006; 98(23):1707-13. DOI: 10.1093/jnci/djj464. View

11.

Kuhn S, Cabot E, Christ A, Capstick M, Kuster N . Assessment of the radio-frequency electromagnetic fields induced in the human body from mobile phones used with hands-free kits. Phys Med Biol. 2009; 54(18):5493-508. DOI: 10.1088/0031-9155/54/18/010. View

12.

Schuz J, Johansen C . A comparison of self-reported cellular telephone use with subscriber data: agreement between the two methods and implications for risk estimation. Bioelectromagnetics. 2006; 28(2):130-6. DOI: 10.1002/bem.20297. View

13.

Vrijheid M, Armstrong B, Bedard D, Brown J, Deltour I, Iavarone I . Recall bias in the assessment of exposure to mobile phones. J Expo Sci Environ Epidemiol. 2008; 19(4):369-81. DOI: 10.1038/jes.2008.27. View

14.

Schuz J, Waldemar G, Olsen J, Johansen C . Risks for central nervous system diseases among mobile phone subscribers: a Danish retrospective cohort study. PLoS One. 2009; 4(2):e4389. PMC: 2632742. DOI: 10.1371/journal.pone.0004389. View

15.

Johansen C, Boice Jr J, McLaughlin J, Olsen J . Cellular telephones and cancer--a nationwide cohort study in Denmark. J Natl Cancer Inst. 2001; 93(3):203-7. DOI: 10.1093/jnci/93.3.203. View

16.

Roosli M, Michel G, Kuehni C, Spoerri A . Cellular telephone use and time trends in brain tumour mortality in Switzerland from 1969 to 2002. Eur J Cancer Prev. 2007; 16(1):77-82. DOI: 10.1097/01.cej.0000203618.61936.cd. View

17.

Lonn S, Klaeboe L, Hall P, Mathiesen T, Auvinen A, Christensen H . Incidence trends of adult primary intracerebral tumors in four Nordic countries. Int J Cancer. 2003; 108(3):450-5. DOI: 10.1002/ijc.11578. View

18.

Ahlbom A, Feychting M, Green A, Kheifets L, Savitz D, Swerdlow A . Epidemiologic evidence on mobile phones and tumor risk: a review. Epidemiology. 2009; 20(5):639-52. DOI: 10.1097/EDE.0b013e3181b0927d. View

19.

Schuz J, Steding-Jessen M, Hansen S, Stangerup S, Caye-Thomasen P, Poulsen A . Long-term mobile phone use and the risk of vestibular schwannoma: a Danish nationwide cohort study. Am J Epidemiol. 2011; 174(4):416-22. DOI: 10.1093/aje/kwr112. View

20.

Olsen J, Friis S, Frederiksen K, McLaughlin J, Mellemkjaer L, Moller H . Atypical cancer pattern in patients with Parkinson's disease. Br J Cancer. 2004; 92(1):201-5. PMC: 2361753. DOI: 10.1038/sj.bjc.6602279. View