Age-related Neointimal Hyperplasia is Associated with Monocyte Infiltration After Balloon Angioplasty

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2011 Oct 22

PMID 22016364

Citations 9

Authors

Sammy D D Eghbalieh

Paraag Chowdhary

Akihito Muto

Kenneth R Ziegler

Fabio A Kudo

Jose M Pimiento

Issa Mirmehdi

Lynn S Model

Yuka Kondo

Toshiya Nishibe

Alan Dardik

Affiliations

Soon will be listed here.

Abstract

Carotid angioplasty is associated with adverse events in elderly patients; it is unclear whether this is related to an altered inflammatory axis. The carotid arteries of young (6 months) or aged (22-24 months) Fischer 344 rats were balloon injured. Aged rats had reduced lumen area (0.18 ± 0.03 vs 0.24 ± 0.01 mm(2), p = .02) and increased neointimal thickening (0.15 ± 0.04 vs 0.08 ± 0.03 mm(2), p = .006). Aged rats had increased circulating monocytes (96 ± 21 vs. 54 ± 7; p = .002) as well as increased numbers of monocytes at the post-angioplasty site. Aged rats had sustained monocyte chemotactic protein-1 expression after angioplasty but young rats did not. Aged arteries also exhibited defective vasorelaxation and abnormal eNOS localization. Aged (≥80 years) human patients with high-grade carotid stenosis had increased number of monocytes (9.1% ± 0.4%) compared with younger (65-80 years) patients (8.1% ± 0.3%, p = .013). Aged rats develop neointimal hyperplasia after carotid angioplasty with increased numbers of monocytes, and elderly humans with carotid stenosis have increased numbers of circulating monocytes. These preliminary results may suggest a role for monocytes in the response to carotid angioplasty.

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