Imaging the Coordination of Multiple Signalling Activities in Living Cells

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2011 Oct 22

PMID 22016058

Citations 76

Authors

Christopher M Welch

Hunter Elliott

Gaudenz Danuser

Klaus M Hahn

Affiliations

Soon will be listed here.

Abstract

Cellular signal transduction occurs in complex and redundant interaction networks, which are best understood by simultaneously monitoring the activation dynamics of multiple components. Recent advances in biosensor technology have made it possible to visualize and quantify the activation of multiple network nodes in the same living cell. The precision and scope of this approach has been greatly extended by novel computational approaches (referred to as computational multiplexing) that can reveal relationships between network nodes imaged in separate cells.

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