The N-end Rule Pathway: Emerging Functions and Molecular Principles of Substrate Recognition

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2011 Oct 22

PMID 22016057

Citations 103

Authors

Shashikanth M Sriram

Bo Yeon Kim

Yong Tae Kwon

Affiliations

Soon will be listed here.

Abstract

The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue and its post-translational modification. Since its discovery 25 years ago, the pathway involved in the N-end rule has been thought to target only a limited set of specific substrates of the ubiquitin-proteasome system. Recent studies have provided insights into the components, substrates, functions and structural basis of substrate recognition. The N-end rule pathway is now emerging as a major cellular proteolytic system, in which the majority of proteins are born with or acquire specific N-terminal degradation determinants through protein-specific or global post-translational modifications.

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