Non-classical MHC-Ι Genes in Chronic Hepatitis B and Hepatocellular Carcinoma

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 2011 Oct 22

PMID 22015712

Citations 7

Authors

Jian Zhang

Lelin Pan

Luyan Chen

Xiaowen Feng

Lin Zhou

Shusen Zheng

Affiliations

Soon will be listed here.

Abstract

The non-classical human leukocyte antigens (HLA)-E, HLA-G, and HLA-F have been shown to modulate immune responses. We examined whether non-classical HLA polymorphisms are associated with hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Fifteen Single-nucleotide polymorphisms (SNPs) in these non-classical class I alleles were investigated by ligase detection reaction. A fragment of 650 bp located in the 3' untranslated region of HLA-G was investigated. Four SNPs (rs17875380, rs41557518, rs114465251, and rs115492845) were associated with altered susceptibility to HBV or HCC, and HLA-F*01:04, HLA-G*01:05N, and HLA-E*01:01 were associated with hepatitis B or hepatitis B complicated with HCC. Six of 16 designated HLA-E, -G, and -F haplotypes were associated with risk of hepatitis B or HCC. Our study provides healthy reference and detailed analyses of non-classical HLA class Ι polymorphisms that provide insight into immune mechanisms involved in susceptibility to hepatitis B and HCC.

Citing Articles

Non-Classical HLA Class 1b and Hepatocellular Carcinoma.

De Re V, Tornesello M, Racanelli V, Prete M, Steffan A Biomedicines. 2023; 11(6).

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Dimorphism of HLA-E and its Disease Association.

Kanevskiy L, Erokhina S, Kobyzeva P, Streltsova M, Sapozhnikov A, Kovalenko E Int J Mol Sci. 2019; 20(21).

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Human leukocyte antigen (HLA-F) polymorphism is associated with chronic HBV infection.

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Human Leukocyte Antigen-E Alleles are Associated with Hepatitis C Virus, Torque Teno Virus, and Toxoplasma Co-infections but are not Associated with Hepatitis B Virus, Hepatitis D Virus, and GB Virus C Co-infections in Human Immunodeficiency Virus....

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Clinical Relevance of HLA Gene Variants in HBV Infection.

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