Polyunsaturated Fatty Acid Metabolism in Prostate Cancer

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2011 Oct 22

PMID 22015690

Citations 48

Authors

Isabelle M Berquin

Iris J Edwards

Steven J Kridel

Yong Q Chen

Affiliations

Soon will be listed here.

Abstract

Polyunsaturated fatty acids (PUFA) play important roles in the normal physiology and in pathological states including inflammation and cancer. While much is known about the biosynthesis and biological activities of eicosanoids derived from ω6 PUFA, our understanding of the corresponding ω3 series lipid mediators is still rudimentary. The purpose of this review is not to offer a comprehensive summary of the literature on fatty acids in prostate cancer but rather to highlight some of the areas where key questions remain to be addressed. These include substrate preference and polymorphic variants of enzymes involved in the metabolism of PUFA, the relationship between de novo lipid synthesis and dietary lipid metabolism pathways, the contribution of cyclooxygenases and lipoxygenases as well as terminal synthases and prostanoid receptors in prostate cancer, and the potential role of PUFA in angiogenesis and cell surface receptor signaling.

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References

Xie L, Innis S . Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation. J Nutr. 2008; 138(11):2222-8. DOI: 10.3945/jn.108.096156. View

Ornitz D, Itoh N . Fibroblast growth factors. Genome Biol. 2001; 2(3):REVIEWS3005. PMC: 138918. DOI: 10.1186/gb-2001-2-3-reviews3005. View

Faronato M, Muzzonigro G, Milanese G, Menna C, Bonfigli A, Catalano A . Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma. Histol Histopathol. 2007; 22(10):1109-18. DOI: 10.14670/HH-22.1109. View

Swinnen J, Verhoeven G . Androgens and the control of lipid metabolism in human prostate cancer cells. J Steroid Biochem Mol Biol. 1998; 65(1-6):191-8. DOI: 10.1016/s0960-0760(97)00187-8. View

Merino D, Ma D, Mutch D . Genetic variation in lipid desaturases and its impact on the development of human disease. Lipids Health Dis. 2010; 9:63. PMC: 2914715. DOI: 10.1186/1476-511X-9-63. View

Simopoulos A . Essential fatty acids in health and chronic disease. Am J Clin Nutr. 1999; 70(3 Suppl):560S-569S. DOI: 10.1093/ajcn/70.3.560s. View

Paone A, Galli R, Gabellini C, Lukashev D, Starace D, Gorlach A . Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha. Neoplasia. 2010; 12(7):539-49. PMC: 2907580. DOI: 10.1593/neo.92106. View

Hayashi T, Nishiyama K, Shirahama T . Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells. Int J Urol. 2006; 13(8):1086-91. DOI: 10.1111/j.1442-2042.2006.01485.x. View

Valta M, Tuomela J, Vuorikoski H, Loponen N, Vaananen R, Pettersson K . FGF-8b induces growth and rich vascularization in an orthotopic PC-3 model of prostate cancer. J Cell Biochem. 2009; 107(4):769-84. DOI: 10.1002/jcb.22175. View

10.

Malerba G, Schaeffer L, Xumerle L, Klopp N, Trabetti E, Biscuola M . SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease. Lipids. 2008; 43(4):289-99. DOI: 10.1007/s11745-008-3158-5. View

11.

Martinelli N, Consoli L, Olivieri O . A 'desaturase hypothesis' for atherosclerosis: Janus-faced enzymes in omega-6 and omega-3 polyunsaturated fatty acid metabolism. J Nutrigenet Nutrigenomics. 2009; 2(3):129-39. DOI: 10.1159/000238177. View

12.

PICKETT W, Ramesha C . Ether phospholipids in control and 20:4-depleted rat PMN: additional evidence for a 1-O-alkyl-2-20:4-sn-glycerol-3-phosphocholine specific phospholipase A2. Agents Actions. 1987; 21(3-4):390-2. DOI: 10.1007/BF01966525. View

13.

Horrobin D, Huang Y, Cunnane S, Manku M . Essential fatty acids in plasma, red blood cells and liver phospholipids in common laboratory animals as compared to humans. Lipids. 1984; 19(10):806-11. DOI: 10.1007/BF02534476. View

14.

Lattka E, Illig T, Heinrich J, Koletzko B . FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases. J Nutrigenet Nutrigenomics. 2009; 2(3):119-28. DOI: 10.1159/000235559. View

15.

Frigola J, Munoz M, Clark S, Moreno V, Capella G, Peinado M . Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy. Oncogene. 2005; 24(49):7320-6. DOI: 10.1038/sj.onc.1208883. View

16.

Chakravarthy M, Lodhi I, Yin L, Malapaka R, Xu H, Turk J . Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell. 2009; 138(3):476-88. PMC: 2725194. DOI: 10.1016/j.cell.2009.05.036. View

17.

Hatzivassiliou G, Zhao F, Bauer D, Andreadis C, Shaw A, Dhanak D . ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell. 2005; 8(4):311-21. DOI: 10.1016/j.ccr.2005.09.008. View

18.

Panigrahy D, Kaipainen A, Greene E, Huang S . Cytochrome P450-derived eicosanoids: the neglected pathway in cancer. Cancer Metastasis Rev. 2010; 29(4):723-35. PMC: 2962793. DOI: 10.1007/s10555-010-9264-x. View

19.

Swinnen J, Van Veldhoven P, Timmermans L, De Schrijver E, Brusselmans K, Vanderhoydonc F . Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun. 2003; 302(4):898-903. DOI: 10.1016/s0006-291x(03)00265-1. View

20.

Poole E, Bigler J, Whitton J, Sibert J, Potter J, Ulrich C . Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. Cancer Epidemiol Biomarkers Prev. 2006; 15(3):502-8. DOI: 10.1158/1055-9965.EPI-05-0804. View