Factors Associated with Inflammation Markers, a Cross-sectional Analysis

Overview

Journal Cytokine

Specialties Allergy & Immunology
Biology

Date 2011 Oct 22

PMID 22015105

Citations 27

Authors

Tess V Clendenen

Karen L Koenig

Alan A Arslan

Annekatrin Lukanova

Franco Berrino

Yian Gu

Goran Hallmans

Annika Idahl

Vittorio Krogh

Anna E Lokshin

Eva Lundin

Paola Muti

Adele Marrangoni

Brian M Nolen

Nina Ohlson

Roy E Shore

Sabina Sieri

Anne Zeleniuch-Jacquotte

Affiliations

Soon will be listed here.

Abstract

Epidemiological studies have reported associations between circulating inflammation markers and risk of chronic diseases. It is of interest to examine whether risk factors for these diseases are associated with inflammation. We conducted a cross-sectional analysis to evaluate whether reproductive and lifestyle factors and circulating vitamin D were associated with inflammation markers, including C-reactive protein, cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα), and cytokine modulators (IL-1RA, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1/R2), among 616 healthy women. We confirmed associations of several inflammation markers with age and BMI. We also observed significantly higher levels of certain inflammation markers in postmenopausal vs. premenopausal women (TNFα, sIL-1RII, sIL-2Ra), with increasing parity (IL-12p40), and with higher circulating 25(OH) vitamin D (IL-13) and lower levels among current users of non-steroidal anti-inflammatory drugs (NSAIDs) (IL-1β, IL-2, IL-10, IL-12p70, and IL-12p40), current smokers (IL-4, IL-13, IL-12p40), and women with a family history of breast or ovarian cancer (IL-4, IL-10, IL-13). Our findings suggest that risk factors for chronic diseases (age, BMI, menopausal status, parity, NSAID use, family history of breast and ovarian cancer, and smoking) are associated with inflammation markers in healthy women.

Citing Articles

Sex-biased genetic regulation of inflammatory proteins in the Dutch population.

Boahen C, Abee H, Ricano Ponce I, Joosten L, Netea M, Kumar V BMC Genomics. 2024; 25(1):154.

PMID: 38326779 PMC: 10851559. DOI: 10.1186/s12864-024-10065-z.

Changes of acute-phase proteins, glucose, and lipid metabolism during pregnancy in lactating dairy cows.

Fazio E, Bionda A, Liotta L, Amato A, Chiofalo V, Crepaldi P Arch Anim Breed. 2022; 65(3):329-339.

PMID: 36267480 PMC: 9562691. DOI: 10.5194/aab-65-329-2022.

Association between parity and markers of inflammation: The multi-ethnic study of atherosclerosis.

Ezeigwe A, Ogunmoroti O, Minhas A, Rodriguez C, Kazzi B, Fashanu O Front Cardiovasc Med. 2022; 9:922367.

PMID: 36186982 PMC: 9515387. DOI: 10.3389/fcvm.2022.922367.

Host characteristics associated with serologic inflammatory biomarkers in women.

Wang S, Zhong C, Epeldegui M, Nunes S, Magpantay L, Clague DeHart J Cytokine. 2021; 149:155726.

PMID: 34666235 PMC: 8680201. DOI: 10.1016/j.cyto.2021.155726.

The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.

Poles J, Karhu E, McGill M, McDaniel H, Lewis J J Clin Transl Res. 2021; 7(3):333-376.

PMID: 34239993 PMC: 8259612.

References

Arslan A, Clendenen T, Koenig K, Hultdin J, Enquist K, Agren A . Circulating vitamin d and risk of epithelial ovarian cancer. J Oncol. 2009; 2009:672492. PMC: 2735000. DOI: 10.1155/2009/672492. View

Hosnijeh F, J M Krop E, Scoccianti C, Krogh V, Palli D, Panico S . Plasma cytokines and future risk of non-Hodgkin lymphoma (NHL): a case-control study nested in the Italian European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2010; 19(6):1577-84. DOI: 10.1158/1055-9965.EPI-09-1237. View

Ikonomidis I, Andreotti F, Economou E, Stefanadis C, Toutouzas P, Nihoyannopoulos P . Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin. Circulation. 1999; 100(8):793-8. DOI: 10.1161/01.cir.100.8.793. View

Purdue M, Lan Q, Bagni R, Hocking W, Baris D, Reding D . Prediagnostic serum levels of cytokines and other immune markers and risk of non-hodgkin lymphoma. Cancer Res. 2011; 71(14):4898-907. PMC: 3138883. DOI: 10.1158/0008-5472.CAN-11-0165. View

Gu Y, Shore R, Arslan A, Koenig K, Liu M, Ibrahim S . Circulating cytokines and risk of B-cell non-Hodgkin lymphoma: a prospective study. Cancer Causes Control. 2010; 21(8):1323-33. PMC: 3111139. DOI: 10.1007/s10552-010-9560-3. View

Feldman M, Jialal I, Devaraj S, Cryer B . Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay. J Am Coll Cardiol. 2001; 37(8):2036-41. DOI: 10.1016/s0735-1097(01)01289-x. View

Shea M, Booth S, Massaro J, Jacques P, DAgostino Sr R, Dawson-Hughes B . Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2007; 167(3):313-20. PMC: 3151653. DOI: 10.1093/aje/kwm306. View

Ahonen T, Kautiainen H, Keinanen-Kiukaanniemi S, Kumpusalo E, Vanhala M . Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein. Am J Prev Med. 2008; 35(6):598-601. DOI: 10.1016/j.amepre.2008.09.011. View

Gannage-Yared M, Azoury M, Mansour I, Baddoura R, Halaby G, Naaman R . Effects of a short-term calcium and vitamin D treatment on serum cytokines, bone markers, insulin and lipid concentrations in healthy post-menopausal women. J Endocrinol Invest. 2003; 26(8):748-53. DOI: 10.1007/BF03347358. View

10.

Pantsulaia I, Pantsulaia I, Trofimov S, Kobyliansky E, Livshits G . Genetic and environmental influences on IL-6 and TNF-alpha plasma levels in apparently healthy general population. Cytokine. 2002; 19(3):138-46. DOI: 10.1006/cyto.2002.1959. View

11.

Mitsuyama K, Toyonaga A, Sasaki E, Ishida O, Ikeda H, Tsuruta O . Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. Gut. 1995; 36(1):45-9. PMC: 1382351. DOI: 10.1136/gut.36.1.45. View

12.

Levitzky Y, Guo C, Rong J, Larson M, Walter R, Keaney Jr J . Relation of smoking status to a panel of inflammatory markers: the framingham offspring. Atherosclerosis. 2008; 201(1):217-24. PMC: 2783981. DOI: 10.1016/j.atherosclerosis.2007.12.058. View

13.

McSorley M, Alberg A, Allen D, Allen N, Brinton L, Dorgan J . C-reactive protein concentrations and subsequent ovarian cancer risk. Obstet Gynecol. 2007; 109(4):933-41. DOI: 10.1097/01.AOG.0000257126.68803.03. View

14.

Zheng W, Danforth K, Tworoger S, Goodman M, Arslan A, Patel A . Circulating 25-hydroxyvitamin D and risk of epithelial ovarian cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 2010; 172(1):70-80. PMC: 2892541. DOI: 10.1093/aje/kwq118. View

15.

Lubin J, Colt J, Camann D, Davis S, Cerhan J, Severson R . Epidemiologic evaluation of measurement data in the presence of detection limits. Environ Health Perspect. 2004; 112(17):1691-6. PMC: 1253661. DOI: 10.1289/ehp.7199. View

16.

Clendenen T, Lundin E, Zeleniuch-Jacquotte A, Koenig K, Berrino F, Lukanova A . Circulating inflammation markers and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2011; 20(5):799-810. PMC: 3089656. DOI: 10.1158/1055-9965.EPI-10-1180. View

17.

Vignali D . Multiplexed particle-based flow cytometric assays. J Immunol Methods. 2000; 243(1-2):243-55. DOI: 10.1016/s0022-1759(00)00238-6. View

18.

Sites C, Toth M, Cushman M, LHommedieu G, Tchernof A, Tracy R . Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal. Fertil Steril. 2002; 77(1):128-35. DOI: 10.1016/s0015-0282(01)02934-x. View

19.

Tracy R, Psaty B, Macy E, Bovill E, Cushman M, Cornell E . Lifetime smoking exposure affects the association of C-reactive protein with cardiovascular disease risk factors and subclinical disease in healthy elderly subjects. Arterioscler Thromb Vasc Biol. 1997; 17(10):2167-76. DOI: 10.1161/01.atv.17.10.2167. View

20.

Yasui T, Maegawa M, Tomita J, Miyatani Y, Yamada M, Uemura H . Changes in serum cytokine concentrations during the menopausal transition. Maturitas. 2006; 56(4):396-403. DOI: 10.1016/j.maturitas.2006.11.002. View