Genetics of Behçet's Disease

Overview

Journal Patholog Res Int

Publisher Hindawi

Specialty Pathology

Date 2011 Oct 21

PMID 22013548

Citations 19

Authors

Tamer Irfan Kaya

Affiliations

Soon will be listed here.

Abstract

Behçet's disease (BD) is a systemic inflammatory disorder characterized mainly by recurrent oral and genital ulcers and eye involvement. Although the pathogenesis remains poorly understood, a variety of studies have demonstrated that genetic predisposition is a major factor in disease susceptibility. Peculiar geographical distribution of BD along the ancient Silk Road has been regarded as evidence supporting genetic influence. The observed aggregation of BD in families of patients with BD is also supportive for a genetic component in its etiology. HLA-B51 (B510101 subtype) is the most strongly associated genetic marker for BD in countries on the Silk Road. In recent years, several genome-wide association studies and genetic polymorphism studies have also found new genetic associations with BD, which may have a supplementary role in disease susceptibility and/or severity. The author reviewed the HLA and non-HLA genetic association studies.

Citing Articles

Genetic testing of Behçet's disease using next-generation sequencing to identify monogenic mimics and HLA-B*51.

Burleigh A, Omoyinmi E, Papadopoulou C, Al-Abadi E, Hong Y, Price-Kuehne F Rheumatology (Oxford). 2023; 63(12):3457-3470.

PMID: 38006337 PMC: 11636563. DOI: 10.1093/rheumatology/kead628.

The relationship between HLA-B*51 subtypes, clinical manifestations and severity of Behçet's syndrome: a large Italian cohort study.

Leccese P, Padula M, Santospirito E, Colucci R, Lascaro N, Padula A Rheumatol Adv Pract. 2023; 7(3):rkad087.

PMID: 37937176 PMC: 10627283. DOI: 10.1093/rap/rkad087.

Autoimmune Heart Disease: A Comprehensive Summary for Forensic Practice.

Mezzetti E, Costantino A, Leoni M, Pieretti R, DI Paolo M, Frati P Medicina (Kaunas). 2023; 59(8).

PMID: 37629654 PMC: 10456745. DOI: 10.3390/medicina59081364.

The HLA-G Immune Checkpoint Plays a Pivotal Role in the Regulation of Immune Response in Autoimmune Diseases.

Zaborek-Lyczba M, Lyczba J, Mertowska P, Mertowski S, Hymos A, Podgajna M Int J Mol Sci. 2021; 22(24).

PMID: 34948145 PMC: 8706866. DOI: 10.3390/ijms222413348.

Pathergy test with a 23G needle with and without self-saliva in patients with Behçet's disease, recurrent aphthous stomatitis and control group compared to the 20G test.

Shenavandeh S, Sadeghi S, Aflaki E Reumatologia. 2021; 59(5):302-308.

PMID: 34819704 PMC: 8609381. DOI: 10.5114/reum.2021.110567.

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