Tumor Suppressors and Cell-cycle Proteins in Lung Cancer

Overview

Journal Patholog Res Int

Publisher Hindawi

Specialty Pathology

Date 2011 Oct 19

PMID 22007345

Citations 20

Authors

Alfonso Baldi

Antonio De Luca

Vincenzo Esposito

Mara Campioni

Enrico P Spugnini

Gennaro Citro

Affiliations

Soon will be listed here.

Abstract

The cell cycle is the cascade of events that allows a growing cell to duplicate all its components and split into two daughter cells. Cell cycle progression is mediated by the activation of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors grouped into two families: the INK4 inhibitors (p16, p15, p19, and p18) and the Cip/Kip inhibitors (p21, p27, and p53). Several studies report the importance of cell-cycle proteins in the pathogenesis and the prognosis of lung cancer. This paper will review the most recent data from the literature about the regulation of cell cycle. Finally, based essentially on the data generated in our laboratory, the expression, the diagnostic, and prognostic significance of cell-cycle molecules in lung cancer will be examined.

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