The Influence of Schizophyllum Commune on Asthma Severity

Overview

Journal Lung

Specialty Pulmonary Medicine

Date 2011 Oct 19

PMID 22006653

Citations 8

Authors

Haruhiko Ogawa

Masaki Fujimura

Yasuo Takeuchi

Koichi Makimura

Affiliations

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Abstract

Background: The sensitization and exposure to fungal allergens have been reported to be associated with asthma. The aim of this study was to clarify the impact of sensitization to Schizophyllum commune (S. commune) on the severity and exacerbations of asthma.

Methods: Ninety-two patients with asthma of various levels of severity [mild (n = 18), moderate (28), and severe (46)] and exacerbation severity [moderate (n = 43) and severe (6)] were retrospectively examined with regard to fungal sensitization such as specific IgE or intradermal skin reactions against S. commune and other common allergens. We also classified the patients into three groups: (1) three or more asthma attacks during the past year (F-BA) (n = 29),(2) one or two asthma attacks (NF-BA) (n = 20), and (3) no asthma attack (C-BA) (n = 43).

Results: The positive rate of late cutaneous reactions to S. commune was higher in patients with severe asthma (41.2%) than with moderate (26.1%) or mild asthma (6.7%), and was significantly different among the three groups (P < 0.05). Although the ratio did not show a significant difference between the patients with severe (83.3%) or moderate (36.1%) exacerbation, it was higher in F-BA (60.9%) than in NF-BA (21.1%) and C-BA patients (10.0%), and it was significantly different among the three groups (P = 0.0002). Multivariate analysis identified positive results for late-phase skin reactions to S. commune and the age of the patients as an independent determinant of asthma severity, and the skin results and %FVC an independent determinant of exacerbation frequency.

Conclusion: This study demonstrated that S. commune is an environmental fungus that appears to enhance both the severity of asthma and the exacerbation frequency.

Citing Articles

The Interactions of Airway Bacterial and Fungal Communities in Clinically Stable Asthma.

Liu H, Li C, Liang Z, Zhang S, Yang W, Ye Y Front Microbiol. 2020; 11:1647.

PMID: 32849339 PMC: 7396634. DOI: 10.3389/fmicb.2020.01647.

Schizophyllum commune induces IL-17-mediated neutrophilic airway inflammation in OVA-induced asthma model mice.

Hanashiro J, Muraosa Y, Toyotome T, Hirose K, Watanabe A, Kamei K Sci Rep. 2019; 9(1):19321.

PMID: 31852931 PMC: 6920419. DOI: 10.1038/s41598-019-55836-x.

Schizophyllum commune-induced Pulmonary Mycosis.

Shen Q, Yao Y, Yang Q, Zhou J Chin Med J (Engl). 2016; 129(17):2141-2.

PMID: 27569249 PMC: 5009606. DOI: 10.4103/0366-6999.189062.

Filamentous Fungi in Respiratory Infections. What Lies Beyond Aspergillosis and Mucormycosis?.

Chowdhary A, Agarwal K, Meis J PLoS Pathog. 2016; 12(4):e1005491.

PMID: 27124489 PMC: 4849718. DOI: 10.1371/journal.ppat.1005491.

Schizophyllum commune-induced allergic fungal rhinosinusitis and sinobronchial mycosis.

Tsukatani T, Ogawa H, Anzawa K, Kobayashi E, Hasegawa H, Makimura K Med Mycol Case Rep. 2015; 8:10-3.

PMID: 25756007 PMC: 4348453. DOI: 10.1016/j.mmcr.2015.02.004.

References

Denning D, ODriscoll B, Powell G, Chew F, Atherton G, Vyas A . Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med. 2008; 179(1):11-8. DOI: 10.1164/rccm.200805-737OC. View

Helbling A, Brander K, Horner W, Lehrer S . Allergy to basidiomycetes. Chem Immunol. 2002; 81:28-47. DOI: 10.1159/000058861. View

Platts-Mills T, Woodfolk J . Trichophyton asthma. Chest. 2009; 135(4):887-888. DOI: 10.1378/chest.09-0114. View

Jung J, Choi J, Shin J, Kim J, Park I, Choi B . Clinical characteristics according to sensitized allergens in adult korean patients with bronchial asthma. Allergy Asthma Immunol Res. 2010; 2(2):102-7. PMC: 2846732. DOI: 10.4168/aair.2010.2.2.102. View

Neukirch C, Henry C, Leynaert B, Liard R, Bousquet J, Neukirch F . Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study. J Allergy Clin Immunol. 1999; 103(4):709-11. DOI: 10.1016/s0091-6749(99)70247-2. View

Van Hoeyveld E, Dupont L, Bossuyt X . Quantification of IgG antibodies to Aspergillus fumigatus and pigeon antigens by ImmunoCAP technology: an alternative to the precipitation technique?. Clin Chem. 2006; 52(9):1785-93. DOI: 10.1373/clinchem.2006.067546. View

Mungan D, Bavbek S, Peksari V, Celik G, Gugey E, Misirligil Z . Trichophyton sensitivity in allergic and nonallergic asthma. Allergy. 2001; 56(6):558-62. DOI: 10.1034/j.1398-9995.2001.056006558.x. View

Ogawa H, Fujimura M, Takeuchi Y, Makimura K . Efficacy of itraconazole in the treatment of patients with chronic cough whose sputa yield basidiomycetous fungi-fungus-associated chronic cough (FACC). J Asthma. 2009; 46(4):407-12. DOI: 10.1080/02770900902846331. View

Ogawa H, Fujimura M, Tofuku Y . Treatment of atopic cough caused by Basidiomycetes antigen with low-dose itraconazol. Lung. 2005; 182(5):279-84. DOI: 10.1007/s00408-004-2509-0. View

10.

Bisgaard H, Bonnelykke K, Sleiman P, Brasholt M, Chawes B, Kreiner-Moller E . Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. Am J Respir Crit Care Med. 2008; 179(3):179-85. DOI: 10.1164/rccm.200809-1436OC. View

11.

Kamei K, Unno H, Nagao K, Kuriyama T, Nishimura K, Miyaji M . Allergic bronchopulmonary mycosis caused by the basidiomycetous fungus Schizophyllum commune. Clin Infect Dis. 1994; 18(3):305-9. DOI: 10.1093/clinids/18.3.305. View

12.

Black P, Udy A, Brodie S . Sensitivity to fungal allergens is a risk factor for life-threatening asthma. Allergy. 2000; 55(5):501-4. DOI: 10.1034/j.1398-9995.2000.00293.x. View

13.

Ogawa H, Fujimura M, Takeuchi Y, Makimura K, Satoh K . The definitive diagnostic process and successful treatment for ABPM caused by Schizophyllum commune: a report of two cases. Allergol Int. 2012; 61(1):163-9. DOI: 10.2332/allergolint.11-CR-0325. View

14.

Ogawa H, Fujimura M, Takeuchi Y, Makimura K . The importance of basidiomycetous fungi cultured from the sputum of chronic idiopathic cough: a study to determine the existence of recognizable clinical patterns to distinguish CIC from non-CIC. Respir Med. 2009; 103(10):1492-7. DOI: 10.1016/j.rmed.2009.04.016. View

15.

Ogawa H, Fujimura M, Takeuchi Y, Makimura K . Is Bjerkandera adusta Important to fungus-associated chronic cough as an allergen? Eight cases' reports. J Asthma. 2009; 46(8):849-55. DOI: 10.3109/02770900903199946. View

16.

Denning D, ODriscoll B, Hogaboam C, Bowyer P, Niven R . The link between fungi and severe asthma: a summary of the evidence. Eur Respir J. 2006; 27(3):615-26. DOI: 10.1183/09031936.06.00074705. View

17.

Amitani R, Nishimura K, Niimi A, Kobayashi H, Nawada R, Murayama T . Bronchial mucoid impaction due to the monokaryotic mycelium of Schizophyllum commune. Clin Infect Dis. 1996; 22(1):146-8. DOI: 10.1093/clinids/22.1.146. View

18.

Reddel H, Taylor D, Bateman E, Boulet L, Boushey H, Busse W . An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009; 180(1):59-99. DOI: 10.1164/rccm.200801-060ST. View

19.

Hirsch T, Hering M, Burkner K, Hirsch D, Leupold W, Kerkmann M . House-dust-mite allergen concentrations (Der f 1) and mold spores in apartment bedrooms before and after installation of insulated windows and central heating systems. Allergy. 2000; 55(1):79-83. DOI: 10.1034/j.1398-9995.2000.00250.x. View

20.

Ogawa H, Fujimura M, Takeuchi Y, Makimura K . Two cases of Schizophyllum asthma: is this a new clinical entity or a precursor of ABPM?. Pulm Pharmacol Ther. 2011; 24(5):559-62. DOI: 10.1016/j.pupt.2011.04.030. View