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Feline Histoplasmosis in Brazil: Clinical and Laboratory Aspects and a Comparative Approach of Published Reports

Abstract

The present study described clinical and epidemiological aspects of three cases of feline histoplasmosis and compared them to previously described cases. A detailed mycological identification and antifungal susceptibility profile of each isolate are presented. Secondarily, a serological survey for anti-Histoplasma antibodies was performed with domestic and wild cats. Diseased animals presented nodular to ulcerated skin lesions and respiratory disorders as main clinical signs. H. capsulatum var. capsulatum was isolated and the strains showed to be susceptible to antifungal drugs. Considering that feline histoplasmosis is uncommonly observed in veterinary clinics, diagnosis, and clinical management in endemic areas should be improved.

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References
1.
Guimaraes A, Nosanchuk J, Zancope-Oliveira R . DIAGNOSIS OF HISTOPLASMOSIS. Braz J Microbiol. 2010; 37(1):1-13. PMC: 2863343. DOI: 10.1590/S1517-83822006000100001. View

2.
Ferreira-da-Cruz M, Wanke B, Galvao-Castro B . Canine histoplasmosis in Rio de Janeiro: natural and experimental infections. J Med Vet Mycol. 1987; 25(5):319-22. DOI: 10.1080/02681218780000361. View

3.
Bromel C, Sykes J . Histoplasmosis in dogs and cats. Clin Tech Small Anim Pract. 2005; 20(4):227-32. DOI: 10.1053/j.ctsap.2005.07.003. View

4.
Kohler S, Wheat L, Connolly P, Schnizlein-Bick C, Durkin M, Smedema M . Comparison of the echinocandin caspofungin with amphotericin B for treatment of histoplasmosis following pulmonary challenge in a murine model. Antimicrob Agents Chemother. 2000; 44(7):1850-4. PMC: 89973. DOI: 10.1128/AAC.44.7.1850-1854.2000. View

5.
Clinkenbeard K, Cowell R, TYLER R . Disseminated histoplasmosis in cats: 12 cases (1981-1986). J Am Vet Med Assoc. 1987; 190(11):1445-8. View