Anaplasma Phagocytophilum Infection Induces Apoptosis in HL-60 Cells

Overview

Journal World J Microbiol Biotechnol

Publisher Springer

Specialties Biotechnology
Microbiology

Date 2011 Oct 18

PMID 22003270

Citations 1

Authors

Pratap Karki

Jacob W IJdo

Affiliations

Soon will be listed here.

Abstract

Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intra-cellular bacterium that survives in neutrophils by delaying apoptosis. The human promyelocytic leukemia cell line HL-60 has been the ultimate choice for culturing Anaplasma in vitro. In this study, we assessed the various events of drug-induced apoptosis in A. phagocytophilum-infected HL-60 cells. Anaplasma infection reduced the cell viability and increased the apoptosis in HL-60 cells and staurosporine or etoposide-induced apoptosis was further exacerbated with Anaplasma infection. Altogether our results suggest that A. phagocytophilum infection is proapoptotic in HL-60 cells unlike in neutrophils where it is antiapoptotic.

Citing Articles

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Artigas-Jeronimo S, Gonzalez-Garcia A, de la Fuente J, Blanda V, Shekarkar Azgomi M, Villar M Vaccines (Basel). 2022; 10(10).

PMID: 36298621 PMC: 9610684. DOI: 10.3390/vaccines10101756.

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