Fatal Dengue Hemorrhagic Fever Imported into Germany

Overview

Journal Infection

Date 2011 Oct 18

PMID 22002736

Citations 16

Authors

J Schmidt-Chanasit

K Tenner-Racz

D Poppert

P Emmerich

C Frank

C Dinges

R Penning

A Nerlich

P Racz

S Gunther

Affiliations

Soon will be listed here.

Abstract

Dengue virus (DENV) is an arthropod-borne virus (family Flaviviridae) causing dengue fever or dengue hemorrhagic fever. Here, we report the first fatal DENV infection imported into Germany. A female traveler was hospitalized with fever and abdominal pain after returning from Ecuador. Due to a suspected acute acalculous cholecystitis, cholecystectomy was performed. After cholecystectomy, severe spontaneous bleeding from the abdominal wound occurred and the patient died. Postmortem analysis of transudate and tissue demonstrated a DENV secondary infection of the patient and a gallbladder wall thickening (GBWT) due to an extensive edema.

Citing Articles

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References

Huerre M, Lan N, Marianneau P, Hue N, Khun H, Hung N . Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch. 2001; 438(2):107-15. DOI: 10.1007/s004280000329. View

Seneviratne S, Malavige G, de Silva H . Pathogenesis of liver involvement during dengue viral infections. Trans R Soc Trop Med Hyg. 2006; 100(7):608-14. DOI: 10.1016/j.trstmh.2005.10.007. View

Schmidt-Chanasit J, Haditsch M, Schoneberg I, Gunther S, Stark K, Frank C . Dengue virus infection in a traveller returning from Croatia to Germany. Euro Surveill. 2010; 15(40). DOI: 10.2807/ese.15.40.19677-en. View

Couvelard A, Marianneau P, Bedel C, Drouet M, Vachon F, Henin D . Report of a fatal case of dengue infection with hepatitis: demonstration of dengue antigens in hepatocytes and liver apoptosis. Hum Pathol. 1999; 30(9):1106-10. DOI: 10.1016/s0046-8177(99)90230-7. View

Schilling S, Emmerich P, Gunther S, Schmidt-Chanasit J . Dengue and Chikungunya virus co-infection in a German traveller. J Clin Virol. 2009; 45(2):163-4. DOI: 10.1016/j.jcv.2009.04.001. View