Involvement of CLEC16A in Activation of Astrocytes After LPS Treated

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2011 Oct 18

PMID 22002632

Citations 15

Authors

Xinmin Wu

Jing Li

Chun Chen

Yaohua Yan

Shengyang Jiang

Xiaohong Wu

Bai Shao

Jin Xu

Lihua Kang

Yeqing Huang

Lin Zhu

Yuhong Ji

Yilu Gao

Affiliations

Soon will be listed here.

Abstract

CLEC16A, C-type lectin domain family 16, member A was recently found to be associated with inflation process in the autoimmune diseases. In this study, we elucidated the dynamic expression changes and localization of CLEC16A in lipopolysaccharide (LPS)-induced neuroinflammatory processes in adult rats. CLEC16A expression was strongly induced in active astrocytes in inflamed cerebral cortex. In vitro studies indicated that the up-regulation of CLEC16A may be involved in the subsequent astrocyte activation following LPS challenge. And Knock-down of CLEC16A in cultured primary astrocytes by siRNA showed that CLEC16A was required for the activation of astrocytes induced by LPS. Collectively, these results suggested CLEC16A may be important in host defense in astrocyte-mediated immune response. Understanding the cell signal pathway may provide a novel strategy against inflammatory and immune reaction in neuroinflammtion in CNS.

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