Microcantilevers Modified by Specific Peptide for Selective Detection of Trimethylamine

Overview

Journal Biosens Bioelectron

Specialties Biochemistry
Biotechnology

Date 2011 Oct 18

PMID 22000756

Citations 1

Authors

Xin Huang

Mingfu Li

Xiaohe Xu

Hongjun Chen

Hai-Feng Ji

Shuifang Zhu

Affiliations

Soon will be listed here.

Abstract

We report a biosensor based on a microcantilever that is modified by a specific peptide for highly selective detection of trimethylamine (TMA). The assay is based on binding-induced bending of the peptide functionalized microcantilevers. The sensor is selectively responsive to TMA. The amplitude of microcantilever bending at equilibrium is a function of the concentration of TMA with a dynamic range from 8 ppm to 800 ppm. The detection limit is approximately 8 ppm. There is a good intra-sensor and an acceptable inter-sensor reproducibility as evidenced by the standard deviation of 5% and 15%, respectively.

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