Uric Acid As a Mediator of Diabetic Nephropathy

Overview

Journal Semin Nephrol

Specialty Nephrology

Date 2011 Oct 18

PMID 22000654

Citations 40

Authors

Diana I Jalal

David M Maahs

Peter Hovind

Takahiko Nakagawa

Affiliations

Soon will be listed here.

Abstract

Despite advances in the management of patients with diabetes, diabetic nephropathy (DN) remains the most common cause of end-stage renal disease in the United States and worldwide. Inflammation and endothelial dysfunction appear to play a central role in the onset and the progression of DN. Recent evidence has emerged in the past decade to suggest uric acid is an inflammatory factor and may play a role in endothelial dysfunction. This has lead our group and others to explore the role of uric acid in the onset and progression of DN. In this review, we highlight some of the animal and human studies that implicate uric acid in DN. Based on the evidence we review, we conclude the need for properly planned randomized controlled studies to decrease uric acid levels and assess the impact of such therapy on diabetic kidney disease.

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