Type I Interferon Response to Extracellular Bacteria in the Airway Epithelium

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2011 Oct 15

PMID 21996313

Citations 35

Authors

Dane Parker

Alice Prince

Affiliations

Soon will be listed here.

Abstract

The airway epithelium possesses many mechanisms to prevent bacterial infection. Not only does it provide a physical barrier, but it also acts as an extension of the immune system through the expression of innate immune receptors and corresponding effectors. One outcome of innate signaling by the epithelium is the production of type I interferons (IFNs), which have traditionally been associated with activation via viral and intracellular organisms. We discuss how three extracellular bacterial pathogens of the airway activate this intracellular signaling cascade through both surface components as well as via secretion systems, and the differing effects of type I IFN signaling on host defense of the respiratory tract.

Citing Articles

Multiple mechanisms enable broad-spectrum activity of the root extract EPs 7630 against acute respiratory tract infections.

Cinatl Jr J, Wass M, Michaelis M Front Pharmacol. 2024; 15:1455870.

PMID: 39469622 PMC: 11513585. DOI: 10.3389/fphar.2024.1455870.

Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis.

Vozza E, Kelly A, Daly C, ORourke S, Carlile S, Morris B Cell Death Discov. 2024; 10(1):403.

PMID: 39271670 PMC: 11399434. DOI: 10.1038/s41420-024-02173-2.

The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation.

Frey A, Lunding L, Wegmann M Cells. 2023; 12(18).

PMID: 37759430 PMC: 10526792. DOI: 10.3390/cells12182208.

Modulation of innate immunity in airway epithelium for host-directed therapy.

Myszor I, Gudmundsson G Front Immunol. 2023; 14:1197908.

PMID: 37251385 PMC: 10213533. DOI: 10.3389/fimmu.2023.1197908.

Pseudomonas aeruginosa Induces Interferon-β Production to Promote Intracellular Survival.

Yang L, Zhang Y, Liu Y, Xie Y, Weng D, Ge B Microbiol Spectr. 2022; 10(5):e0155022.

PMID: 36190409 PMC: 9603546. DOI: 10.1128/spectrum.01550-22.

References

Benveniste E, Qin H . Type I interferons as anti-inflammatory mediators. Sci STKE. 2007; 2007(416):pe70. DOI: 10.1126/stke.4162007pe70. View

Faure K, Sawa T, Ajayi T, Fujimoto J, Moriyama K, Shime N . TLR4 signaling is essential for survival in acute lung injury induced by virulent Pseudomonas aeruginosa secreting type III secretory toxins. Respir Res. 2004; 5:1. PMC: 389879. DOI: 10.1186/1465-9921-5-1. View

Berube J, Bourdon C, Yao Y, Rousseau S . Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells. Cell Signal. 2009; 21(3):448-56. DOI: 10.1016/j.cellsig.2008.12.001. View

Martin F, Gomez M, Wetzel D, Memmi G, OSeaghdha M, Soong G . Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A. J Clin Invest. 2009; 119(7):1931-9. PMC: 2701857. DOI: 10.1172/jci35879. View

Debes G, Dahl M, Mahiny A, Bonhagen K, Campbell D, Siegmund K . Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus. J Immunol. 2005; 176(1):557-66. DOI: 10.4049/jimmunol.176.1.557. View

Mancuso G, Gambuzza M, Midiri A, Biondo C, Papasergi S, Akira S . Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells. Nat Immunol. 2009; 10(6):587-94. DOI: 10.1038/ni.1733. View

Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M . RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol. 2004; 5(5):503-7. DOI: 10.1038/ni1061. View

Kooguchi K, Hashimoto S, Kobayashi A, Kitamura Y, Kudoh I, Wiener-Kronish J . Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia. Infect Immun. 1998; 66(7):3164-9. PMC: 108328. DOI: 10.1128/IAI.66.7.3164-3169.1998. View

Xing Z, Harper R, Anunciacion J, Yang Z, Gao W, Qu B . Host immune and apoptotic responses to avian influenza virus H9N2 in human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol. 2010; 44(1):24-33. PMC: 3159084. DOI: 10.1165/rcmb.2009-0120OC. View

10.

Shornick L, Wells A, Zhang Y, Patel A, Huang G, Takami K . Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection. J Immunol. 2008; 180(5):3319-28. DOI: 10.4049/jimmunol.180.5.3319. View

11.

Deshmukh S, Kremer B, Freudenberg M, Bauer S, Golenbock D, Henneke P . Macrophages recognize streptococci through bacterial single-stranded RNA. EMBO Rep. 2010; 12(1):71-6. PMC: 3024127. DOI: 10.1038/embor.2010.189. View

12.

Hirano T, Ishihara K, Hibi M . Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene. 2000; 19(21):2548-56. DOI: 10.1038/sj.onc.1203551. View

13.

Unterholzner L, Keating S, Baran M, Horan K, Jensen S, Sharma S . IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010; 11(11):997-1004. PMC: 3142795. DOI: 10.1038/ni.1932. View

14.

Kadioglu A, Weiser J, Paton J, Andrew P . The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nat Rev Microbiol. 2008; 6(4):288-301. DOI: 10.1038/nrmicro1871. View

15.

Mayer A, Muehmer M, Mages J, Gueinzius K, Hess C, Heeg K . Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. J Immunol. 2007; 178(5):3134-42. DOI: 10.4049/jimmunol.178.5.3134. View

16.

Carrigan S, Junkins R, Yang Y, MacNeil A, Richardson C, Johnston B . IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice. J Immunol. 2010; 185(6):3602-9. DOI: 10.4049/jimmunol.0903429. View

17.

Yu H, Nasr S, Deretic V . Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis. Infect Immun. 2000; 68(4):2142-7. PMC: 97396. DOI: 10.1128/IAI.68.4.2142-2147.2000. View

18.

Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H . A Toll-like receptor recognizes bacterial DNA. Nature. 2000; 408(6813):740-5. DOI: 10.1038/35047123. View

19.

Liu Y . IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol. 2005; 23:275-306. DOI: 10.1146/annurev.immunol.23.021704.115633. View

20.

Takeuchi O, Akira S . Pattern recognition receptors and inflammation. Cell. 2010; 140(6):805-20. DOI: 10.1016/j.cell.2010.01.022. View