Restricted Access to Myeloid Cells Explained

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2011 Oct 14

PMID 21994799

Citations 9

Authors

Vicente Planelles

Affiliations

Soon will be listed here.

Abstract

The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.

Citing Articles

Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection.

Plitnik T, Sharkey M, Mahboubi B, Kim B, Stevenson M Pathog Immun. 2019; 3(2):197-223.

PMID: 30656243 PMC: 6333473. DOI: 10.20411/pai.v3i2.263.

Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.

Hollenbaugh J, Montero C, Schinazi R, Munger J, Kim B Virology. 2016; 491:106-14.

PMID: 26895248 PMC: 4834987. DOI: 10.1016/j.virol.2016.01.023.

Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.

Wu L ISRN Biochem. 2014; 2013.

PMID: 24523981 PMC: 3918895. DOI: 10.1155/2013/728392.

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells.

Hollenbaugh J, Gee P, Baker J, Daly M, Amie S, Tate J PLoS Pathog. 2013; 9(6):e1003481.

PMID: 23825958 PMC: 3694861. DOI: 10.1371/journal.ppat.1003481.

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons.

St Gelais C, de Silva S, Amie S, Coleman C, Hoy H, Hollenbaugh J Retrovirology. 2012; 9:105.

PMID: 23231760 PMC: 3527137. DOI: 10.1186/1742-4690-9-105.

References

Berger G, Durand S, Fargier G, Nguyen X, Cordeil S, Bouaziz S . APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells. PLoS Pathog. 2011; 7(9):e1002221. PMC: 3178557. DOI: 10.1371/journal.ppat.1002221. View

Shostak L, Ludlow J, Fisk J, Pursell S, Rimel B, Nguyen D . Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 vpr. Exp Cell Res. 1999; 251(1):156-65. DOI: 10.1006/excr.1999.4568. View

Goujon C, Riviere L, Jarrosson-Wuilleme L, Bernaud J, Rigal D, Darlix J . SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. Retrovirology. 2007; 4:2. PMC: 1779362. DOI: 10.1186/1742-4690-4-2. View

Stewart S, Poon B, Jowett J, Chen I . Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. J Virol. 1997; 71(7):5579-92. PMC: 191800. DOI: 10.1128/JVI.71.7.5579-5592.1997. View

Rogel M, Wu L, Emerman M . The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection. J Virol. 1995; 69(2):882-8. PMC: 188655. DOI: 10.1128/JVI.69.2.882-888.1995. View

Wiegand H, Cullen B . Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins. J Virol. 2007; 81(24):13694-9. PMC: 2168862. DOI: 10.1128/JVI.01646-07. View

Crow Y, Livingston J . Aicardi-Goutières syndrome: an important Mendelian mimic of congenital infection. Dev Med Child Neurol. 2008; 50(6):410-6. DOI: 10.1111/j.1469-8749.2008.02062.x. View

Pancio H, Heyden N, Ratner L . The C-terminal proline-rich tail of human immunodeficiency virus type 2 Vpx is necessary for nuclear localization of the viral preintegration complex in nondividing cells. J Virol. 2000; 74(13):6162-7. PMC: 112115. DOI: 10.1128/jvi.74.13.6162-6167.2000. View

Hrecka K, Hao C, Gierszewska M, Swanson S, Kesik-Brodacka M, Srivastava S . Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature. 2011; 474(7353):658-61. PMC: 3179858. DOI: 10.1038/nature10195. View

10.

Stetson D, Ko J, Heidmann T, Medzhitov R . Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell. 2008; 134(4):587-98. PMC: 2626626. DOI: 10.1016/j.cell.2008.06.032. View

11.

Re F, Braaten D, FRANKE E, LUBAN J . Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J Virol. 1995; 69(11):6859-64. PMC: 189600. DOI: 10.1128/JVI.69.11.6859-6864.1995. View

12.

Malim M, Emerman M . HIV-1 accessory proteins--ensuring viral survival in a hostile environment. Cell Host Microbe. 2008; 3(6):388-98. DOI: 10.1016/j.chom.2008.04.008. View

13.

Qiao F, Bowie J . The many faces of SAM. Sci STKE. 2005; 2005(286):re7. DOI: 10.1126/stke.2862005re7. View

14.

Yan N, Regalado-Magdos A, Stiggelbout B, Lee-Kirsch M, Lieberman J . The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol. 2010; 11(11):1005-13. PMC: 2958248. DOI: 10.1038/ni.1941. View

15.

Aghokeng A, Ayouba A, Mpoudi-Ngole E, Loul S, Liegeois F, Delaporte E . Extensive survey on the prevalence and genetic diversity of SIVs in primate bushmeat provides insights into risks for potential new cross-species transmissions. Infect Genet Evol. 2009; 10(3):386-96. PMC: 2844463. DOI: 10.1016/j.meegid.2009.04.014. View

16.

Manel N, Hogstad B, Wang Y, Levy D, Unutmaz D, Littman D . A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 2010; 467(7312):214-7. PMC: 3051279. DOI: 10.1038/nature09337. View

17.

He J, Choe S, Walker R, Di Marzio P, MORGAN D, Landau N . Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J Virol. 1995; 69(11):6705-11. PMC: 189580. DOI: 10.1128/JVI.69.11.6705-6711.1995. View

18.

Zimmerman M, Proudfoot M, Yakunin A, Minor W . Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli. J Mol Biol. 2008; 378(1):215-26. PMC: 2504004. DOI: 10.1016/j.jmb.2008.02.036. View

19.

Ayinde D, Maudet C, Transy C, Margottin-Goguet F . Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?. Retrovirology. 2010; 7:35. PMC: 2867959. DOI: 10.1186/1742-4690-7-35. View

20.

Lafuse W, Brown D, Castle L, Zwilling B . Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein. J Leukoc Biol. 1995; 57(3):477-83. DOI: 10.1002/jlb.57.3.477. View