Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2011 Oct 14

PMID 21994768

Citations 10

Authors

Laura Hertel

Affiliations

Soon will be listed here.

Abstract

Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.

Citing Articles

'Come together'-The Regulatory Interaction of Herpesviral Nuclear Egress Proteins Comprises Both Essential and Accessory Functions.

Hage S, Marschall M Cells. 2022; 11(11).

PMID: 35681532 PMC: 9180862. DOI: 10.3390/cells11111837.

Nuclear Egress.

Draganova E, Thorsen M, Heldwein E Curr Issues Mol Biol. 2020; 41:125-170.

PMID: 32764158 PMC: 8253559. DOI: 10.21775/cimb.041.125.

Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties.

Marschall M, Hage S, Conrad M, Alkhashrom S, Kicuntod J, Schweininger J Viruses. 2020; 12(6).

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Cytoskeletons in the Closet-Subversion in Alphaherpesvirus Infections.

Denes C, Miranda-Saksena M, Cunningham A, Diefenbach R Viruses. 2018; 10(2).

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Replication of Chelonid Herpesvirus 5 in Organotypic Skin Cultures from Hawaiian Green Turtles (Chelonia mydas).

Work T, Dagenais J, Weatherby T, Balazs G, Ackermann M J Virol. 2017; 91(17).

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