Determinants of Body Fat in Infants of Women with Gestational Diabetes Mellitus Differ with Fetal Sex

Overview

Journal Diabetes Care

Specialty Endocrinology

Date 2011 Oct 14

PMID 21994428

Citations 29

Authors

Barbara E Lingwood

Alexandra M Henry

Michael C dEmden

Amanda-Mei Fullerton

Robin H Mortimer

Paul B Colditz

Kim-Anh Le Cao

Leonie K Callaway

Affiliations

Soon will be listed here.

Abstract

Objective: Neonatal adiposity is a well-recognized complication of gestational diabetes mellitus (GDM). This study aimed to identify factors influencing adiposity in male and female infants of women treated for GDM.

Research Design And Methods: This was a prospective study of 84 women with GDM. Daily blood glucose levels (BGLs) were retrieved from glucose meters, and overall mean fasting and mean 2-h postprandial BGLs were calculated for each woman. Infant body composition was measured at birth, and regression analysis was used to identify significant predictors of infant body fat separately in male and female infants.

Results: Maternal fasting BGL was the major predictor of adiposity in male infants but had little relationship to adiposity in female infants. In male infants, percent fat was increased by 0.44% for each 0.1 mmol/L increase in mean maternal fasting BGL. Maternal BMI was the primary predictor in female infants but had little effect in males. In female infants, percent fat was increased by 0.11% for each 1 kg/m(2) increase in maternal prepregnancy BMI.

Conclusions: Fetal sex may influence the impact that treatment strategies for GDM have on infant adiposity.

Citing Articles

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References

Catalano P, Farrell K, Thomas A, Huston-Presley L, Mencin P, de Mouzon S . Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr. 2009; 90(5):1303-13. PMC: 2762159. DOI: 10.3945/ajcn.2008.27416. View

. Standards of medical care in diabetes--2009. Diabetes Care. 2009; 32 Suppl 1:S13-61. PMC: 2613589. DOI: 10.2337/dc09-S013. View

Gately P, Radley D, Cooke C, Carroll S, Oldroyd B, Truscott J . Comparison of body composition methods in overweight and obese children. J Appl Physiol (1985). 2003; 95(5):2039-46. DOI: 10.1152/japplphysiol.00377.2003. View

Catalano P, Kirwan J . Maternal factors that determine neonatal size and body fat. Curr Diab Rep. 2003; 1(1):71-7. DOI: 10.1007/s11892-001-0013-y. View

Ellis K, Yao M, Shypailo R, Urlando A, Wong W, Heird W . Body-composition assessment in infancy: air-displacement plethysmography compared with a reference 4-compartment model. Am J Clin Nutr. 2007; 85(1):90-5. DOI: 10.1093/ajcn/85.1.90. View

Abrams B, Laros Jr R . Prepregnancy weight, weight gain, and birth weight. Am J Obstet Gynecol. 1986; 154(3):503-9. DOI: 10.1016/0002-9378(86)90591-0. View

Yajnik C, Godbole K, Otiv S, Lubree H . Fetal programming of type 2 diabetes: is sex important?. Diabetes Care. 2007; 30(10):2754-5. DOI: 10.2337/dc07-1485. View

Rodriguez G, Ventura P, Samper M, Moreno L, Sarria A, Perez-Gonzalez J . Changes in body composition during the initial hours of life in breast-fed healthy term newborns. Biol Neonate. 2000; 77(1):12-6. DOI: 10.1159/000014189. View

Ehrenberg H, Mercer B, Catalano P . The influence of obesity and diabetes on the prevalence of macrosomia. Am J Obstet Gynecol. 2004; 191(3):964-8. DOI: 10.1016/j.ajog.2004.05.052. View

10.

Fields D, Goran M . Body composition techniques and the four-compartment model in children. J Appl Physiol (1985). 2000; 89(2):613-20. DOI: 10.1152/jappl.2000.89.2.613. View

11.

Pirc L, Owens J, Crowther C, Willson K, De Blasio M, Robinson J . Mild gestational diabetes in pregnancy and the adipoinsular axis in babies born to mothers in the ACHOIS randomised controlled trial. BMC Pediatr. 2007; 7:18. PMC: 1865537. DOI: 10.1186/1471-2431-7-18. View

12.

Uvena-Celebrezze J, Fung C, Thomas A, Hoty A, Huston-Presley L, Amini S . Relationship of neonatal body composition to maternal glucose control in women with gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2003; 12(6):396-401. DOI: 10.1080/jmf.12.6.396.401. View

13.

FOMON S, Haschke F, Ziegler E, Nelson S . Body composition of reference children from birth to age 10 years. Am J Clin Nutr. 1982; 35(5 Suppl):1169-75. DOI: 10.1093/ajcn/35.5.1169. View

14.

Gillman M, Oakey H, Baghurst P, Volkmer R, Robinson J, Crowther C . Effect of treatment of gestational diabetes mellitus on obesity in the next generation. Diabetes Care. 2010; 33(5):964-8. PMC: 2858199. DOI: 10.2337/dc09-1810. View

15.

Landon M, Spong C, Thom E, Carpenter M, Ramin S, Casey B . A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009; 361(14):1339-48. PMC: 2804874. DOI: 10.1056/NEJMoa0902430. View

16.

. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes. 2008; 58(2):453-9. PMC: 2628620. DOI: 10.2337/db08-1112. View

17.

Hoffman L, Nolan C, Wilson J, Oats J, Simmons D . Gestational diabetes mellitus--management guidelines. The Australasian Diabetes in Pregnancy Society. Med J Aust. 1998; 169(2):93-7. DOI: 10.5694/j.1326-5377.1998.tb140192.x. View

18.

Shields B, Knight B, Hopper H, Hill A, Powell R, Hattersley A . Measurement of cord insulin and insulin-related peptides suggests that girls are more insulin resistant than boys at birth. Diabetes Care. 2007; 30(10):2661-6. DOI: 10.2337/dc06-1501. View

19.

Sparks J . Human intrauterine growth and nutrient accretion. Semin Perinatol. 1984; 8(2):74-93. View

20.

Catalano P, Thomas A, Huston-Presley L, Amini S . Increased fetal adiposity: a very sensitive marker of abnormal in utero development. Am J Obstet Gynecol. 2004; 189(6):1698-704. DOI: 10.1016/s0002-9378(03)00828-7. View