Alternative Nuclear Functions for NF-κB Family Members

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2011 Oct 11

PMID 21984965

Citations 17

Authors

Lluis Espinosa

Anna Bigas

Maria Carmen Mulero

Affiliations

Soon will be listed here.

Abstract

The NF-κB signalling pathway regulates many different biological processes from the cellular level to the whole organism. The majority of these functions are completely dependent on the activation of the cytoplasmic IKK kinase complex that leads to IκB degradation and results in the nuclear translocation of specific NF-κB dimers, which, in general, act as transcription factors. Although this is a well-established mechanism of action, several publications have now demonstrated that some members of this pathway display additional functions in the nucleus as regulators of NF-κB-dependent and independent gene expression. In this review, we compiled and put in context most of the data concerning specific nuclear roles for IKK and IκB proteins.

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