Birthweight, Maternal Weight Trajectories and Global DNA Methylation of LINE-1 Repetitive Elements

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2011 Oct 8

PMID 21980406

Citations 79

Authors

Karin B Michels

Holly R Harris

Ludovic Barault

Affiliations

Soon will be listed here.

Abstract

Low birthweight, premature birth, intrauterine growth retardation, and maternal malnutrition have been related to an increased risk of cardiovascular disease, type 2 diabetes mellitus, obesity, and neuropsychiatric disorders later in life. Conversely, high birthweight has been linked to future risk of cancer. Global DNA methylation estimated by the methylation of repetitive sequences in the genome is an indicator of susceptibility to chronic diseases. We used data and biospecimens from an epigenetic birth cohort to explore the association between trajectories of fetal and maternal weight and LINE-1 methylation in 319 mother-child dyads. Newborns with low or high birthweight had significantly lower LINE-1 methylation levels in their cord blood compared to normal weight infants after adjusting for gestational age, sex of the child, maternal age at delivery, and maternal smoking during pregnancy (p = 0.007 and p = 0.036, respectively), but the magnitude of the difference was small. Infants born prematurely also had lower LINE-1 methylation levels in cord blood compared to term infants, and this difference, though small, was statistically significant (p = 0.004). We did not find important associations between maternal prepregnancy BMI or gestational weight gain and global methylation of the cord blood or fetal placental tissue. In conclusion, we found significant differences in cord blood LINE-1 methylation among newborns with low and high birthweight as well as among prematurely born infants. Future studies may elucidate whether chromosomal instabilities or other functional consequences of these changes contribute to the increased risk of chronic diseases among individuals with these characteristics.

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References

Hanson M, Godfrey K, Lillycrop K, Burdge G, Gluckman P . Developmental plasticity and developmental origins of non-communicable disease: theoretical considerations and epigenetic mechanisms. Prog Biophys Mol Biol. 2011; 106(1):272-80. DOI: 10.1016/j.pbiomolbio.2010.12.008. View

Stuebe A, Forman M, Michels K . Maternal-recalled gestational weight gain, pre-pregnancy body mass index, and obesity in the daughter. Int J Obes (Lond). 2009; 33(7):743-52. PMC: 2710391. DOI: 10.1038/ijo.2009.101. View

Morse B, Rotherg P, South V, Spandorfer J, Astrin S . Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma. Nature. 1988; 333(6168):87-90. DOI: 10.1038/333087a0. View

Rideout 3rd W, Eggan K, Jaenisch R . Nuclear cloning and epigenetic reprogramming of the genome. Science. 2001; 293(5532):1093-8. DOI: 10.1126/science.1063206. View

Susser E, Lin S . Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944-1945. Arch Gen Psychiatry. 1992; 49(12):983-8. DOI: 10.1001/archpsyc.1992.01820120071010. View

Fryer A, Emes R, Ismail K, Haworth K, Mein C, Carroll W . Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics. 2010; 6(1):86-94. PMC: 3052917. DOI: 10.4161/epi.6.1.13392. View

Lander E, Linton L, Birren B, Nusbaum C, Zody M, Baldwin J . Initial sequencing and analysis of the human genome. Nature. 2001; 409(6822):860-921. DOI: 10.1038/35057062. View

Heijmans B, Tobi E, Stein A, Putter H, Blauw G, Susser E . Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci U S A. 2008; 105(44):17046-9. PMC: 2579375. DOI: 10.1073/pnas.0806560105. View

Ravelli G, Stein Z, SUSSER M . Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976; 295(7):349-53. DOI: 10.1056/NEJM197608122950701. View

10.

Barker D, WINTER P, Osmond C, Margetts B, Simmonds S . Weight in infancy and death from ischaemic heart disease. Lancet. 1989; 2(8663):577-80. DOI: 10.1016/s0140-6736(89)90710-1. View

11.

Razin A, Riggs A . DNA methylation and gene function. Science. 1980; 210(4470):604-10. DOI: 10.1126/science.6254144. View

12.

Bollati V, Galimberti D, Pergoli L, Dalla Valle E, Barretta F, Cortini F . DNA methylation in repetitive elements and Alzheimer disease. Brain Behav Immun. 2011; 25(6):1078-83. PMC: 3742099. DOI: 10.1016/j.bbi.2011.01.017. View

13.

Adkins R, Krushkal J, Tylavsky F, Thomas F . Racial differences in gene-specific DNA methylation levels are present at birth. Birth Defects Res A Clin Mol Teratol. 2011; 91(8):728-36. PMC: 3429933. DOI: 10.1002/bdra.20770. View

14.

Barker D, Osmond C . Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986; 1(8489):1077-81. DOI: 10.1016/s0140-6736(86)91340-1. View

15.

Chalitchagorn K, Shuangshoti S, Hourpai N, Kongruttanachok N, Tangkijvanich P, Thong-Ngam D . Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene. 2004; 23(54):8841-6. DOI: 10.1038/sj.onc.1208137. View

16.

Schulz W, Steinhoff C, Florl A . Methylation of endogenous human retroelements in health and disease. Curr Top Microbiol Immunol. 2006; 310:211-50. DOI: 10.1007/3-540-31181-5_11. View

17.

Hsiung D, Marsit C, Houseman E, Eddy K, Furniss C, McClean M . Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2007; 16(1):108-14. DOI: 10.1158/1055-9965.EPI-06-0636. View

18.

Florl A, Lower R, Schmitz-Drager B, Schulz W . DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas. Br J Cancer. 1999; 80(9):1312-21. PMC: 2363067. DOI: 10.1038/sj.bjc.6690524. View

19.

Morgan H, Santos F, Green K, Dean W, Reik W . Epigenetic reprogramming in mammals. Hum Mol Genet. 2005; 14 Spec No 1:R47-58. DOI: 10.1093/hmg/ddi114. View

20.

Filiberto A, Maccani M, Koestler D, Wilhelm-Benartzi C, Avissar-Whiting M, Banister C . Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics. 2011; 6(5):566-72. PMC: 3121971. DOI: 10.4161/epi.6.5.15236. View