Don't It Make My Blue Eyes Brown: Heterochromia and Other Abnormalities of the Iris

Overview

Journal Eye (Lond)

Specialty Ophthalmology

Date 2011 Oct 8

PMID 21979861

Citations 15

Authors

I G Rennie

Affiliations

Soon will be listed here.

Abstract

Eye colour is one of the most important characteristics in determining facial appearance. In this paper I shall discuss the anatomy and genetics of normal eye colour, together with a wide and diverse range of conditions that may produce an alteration in normal iris pigmentation or form.

Citing Articles

Lin P, Hung J, Huang Y CMAJ. 2024; 196(17):E610-E611.

PMID: 38719218 PMC: 11073823. DOI: 10.1503/cmaj.231616-f.

Heterochromia caused by Waardenburg syndrome in a 2-month-old infant.

Lin P, Hung J, Huang Y CMAJ. 2024; 196(9):E296.

PMID: 38467409 PMC: 10927287. DOI: 10.1503/cmaj.231616.

Irissometry: Effects of Pupil Size on Iris Elasticity Measured With Video-Based Feature Tracking.

Strauch C, Naber M Invest Ophthalmol Vis Sci. 2022; 63(2):20.

PMID: 35142787 PMC: 8842542. DOI: 10.1167/iovs.63.2.20.

Topography and clinical features of iris melanoma.

Krohn J, Sundal K, Froystein T BMC Ophthalmol. 2022; 22(1):6.

PMID: 34980044 PMC: 8725464. DOI: 10.1186/s12886-021-02236-3.

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate ().

Colman K, Andrews R, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A J Toxicol Pathol. 2021; 34(3 Suppl):1S-182S.

PMID: 34712008 PMC: 8544165. DOI: 10.1293/tox.34.1S.

References

BERCHER L, Zografos L, Egger E, Chamot L, Uffer S, GAILLOUD C . [Ocular melanocytosis, oculodermal melanocytosis and choroid melanomas]. Klin Monbl Augenheilkd. 1991; 198(5):361-4. DOI: 10.1055/s-2008-1045981. View

Waeltermann J, Hettinger M, Cibis G . Congenital cysts of the iris stroma. Am J Ophthalmol. 1985; 100(4):549-54. DOI: 10.1016/0002-9394(85)90680-4. View

Sagoo M, Shields C, Eagle Jr R, Materin M, Ehya H, McQueen B . Brown trabeculectomy bleb from necrotic iris melanocytoma. Acta Ophthalmol Scand. 2007; 85(5):571-2. DOI: 10.1111/j.1600-0420.2006.00833.x. View

Shields J, Shields C, Lois N, Mercado G . Iris cysts in children: classification, incidence, and management. The 1998 Torrence A Makley Jr Lecture. Br J Ophthalmol. 1999; 83(3):334-8. PMC: 1722970. DOI: 10.1136/bjo.83.3.334. View

Shields J, Shields C, Naseripor M, Eagle R, Miller J . Choroidal melanoma in a black patient with oculodermal melanocytosis. Retina. 2002; 22(1):126-8. DOI: 10.1097/00006982-200202000-00029. View

Bordon A, Wray M, Belfort R, McLean I, Burnier M . Choroidal malignant melanoma in association with oculodermal melanocytosis in a black patient. Br J Ophthalmol. 1995; 79(2):191-2. PMC: 505056. DOI: 10.1136/bjo.79.2.191. View

Batioglu F, Gunalp I . Malignant melanomas of the iris. Jpn J Ophthalmol. 1998; 42(4):281-5. DOI: 10.1016/s0021-5155(98)00011-2. View

Damato B, Duke C, Coupland S, Hiscott P, Smith P, Campbell I . Cytogenetics of uveal melanoma: a 7-year clinical experience. Ophthalmology. 2007; 114(10):1925-31. DOI: 10.1016/j.ophtha.2007.06.012. View

Toth-Molnar E, Olah J, Dobozy A, Hammer H . Ocular pigmented findings in patients with dysplastic naevus syndrome. Melanoma Res. 2004; 14(1):43-7. DOI: 10.1097/00008390-200402000-00007. View

10.

Liu X, Newton V, Read A . Waardenburg syndrome type II: phenotypic findings and diagnostic criteria. Am J Med Genet. 1995; 55(1):95-100. DOI: 10.1002/ajmg.1320550123. View

11.

Dryja T, Albert D . Lack of adrenergic influence on the pigmentation of iris nevus cells. Arch Ophthalmol. 1980; 98(11):1996. DOI: 10.1001/archopht.1980.01020040848011. View

12.

Vail D, MERZ E . Embryonic intraepithelial cyst of the ciliary processes. Trans Am Soc Ophthalmol Otolaryngol Allergy. 1951; 49:167-83. View

13.

Bryce I, Pai V, Bradbury J . Spontaneous resolution of iris and cutaneous haemangiomata in diffuse neonatal haemangiomatosis. Eye (Lond). 2000; 13 ( Pt 3a):388-90. DOI: 10.1038/eye.1999.105. View

14.

Szuscik I, Romanowska-Dixon B, Jakubowska B, Orlowska-Heitzman J . [Uveal melanoma in patients with ocular or oculodermal melanocytosis]. Klin Oczna. 2009; 110(10-12):380-3. View

15.

Podolsky M, SRINIVASAN B . Spontaneous hyphema secondary to vascular tuft of pupillary margin of the iris. Arch Ophthalmol. 1979; 97(2):301-2. DOI: 10.1001/archopht.1979.01020010153012. View

16.

Dahlmann A, Benson M . Spontaneous hyphema secondary to iris vascular tufts. Arch Ophthalmol. 2001; 119(11):1728. DOI: 10.1001/archopht.119.11.1728. View

17.

Stone R, SCHEIE H . Periorbital scleroderma associated with heterochromia iridis. Am J Ophthalmol. 1980; 90(6):858-61. DOI: 10.1016/s0002-9394(14)75201-8. View

18.

Graziosi P, Rosmini F, Bonacini M, Ferrigno L, Sperduto R, Milton R . Location and severity of cortical opacities in different regions of the lens in age-related cataract. Invest Ophthalmol Vis Sci. 1996; 37(8):1698-703. View

19.

Kutzbach B, Mendelsohn N, Rath P, Summers C . Sectoral iris heterochromia and retinal pigment variation in 13q-syndrome. J AAPOS. 2007; 11(5):513-5. DOI: 10.1016/j.jaapos.2007.04.012. View

20.

Kiratli H, Irkec M . Melanocytic glaucoma in a child associated with ocular melanocytosis. J Pediatr Ophthalmol Strabismus. 1998; 34(6):380-1. DOI: 10.3928/0191-3913-19971101-12. View