Transient Modification Within a Pool of CD4 T Cells in the Maternal Spleen

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2011 Oct 8

PMID 21977997

Citations 9

Authors

Elizabeth A Bonney

Michelle T Shepard

Peyman Bizargity

Affiliations

Soon will be listed here.

Abstract

Classic models suggest maternal tolerance is dependent on regulation of fetal antigen-specific T cell responses. We hypothesize that factors unique to a particular fetal antigen-specific T cell, rather than the state of pregnancy per se, are important determinants of T cell fate during pregnancy. To investigate the fate of fetal antigen-specific CD4 T cells in the systemic circulation, we examined spleen cells in a CD4 T cell receptor transgenic mouse specific for the male antigen H-Y. We observed a transient decrease in CD4(+) Vβ6(+) cell numbers and, due to transient internalization of CD4, an increase in CD4(-) Vβ6(+) T cells. Antigen-specific in vitro responsiveness was not depressed by pregnancy. These data suggest that pregnancy supports fluidity in this particular CD4 T cell pool that may, in turn, help to meet competing requirements of maternal immune responsiveness and fetal tolerance.

Citing Articles

A Framework for Understanding Maternal Immunity.

Bonney E Immunol Allergy Clin North Am. 2023; 43(1S):e1-e20.

PMID: 37179052 PMC: 10484232. DOI: 10.1016/j.iac.2023.03.002.

Pregnancy imparts distinct systemic adaptive immune function.

Demery-Poulos C, Romero R, Xu Y, Arenas-Hernandez M, Miller D, Tao L Am J Reprod Immunol. 2022; 88(5):e13606.

PMID: 35989229 PMC: 9648024. DOI: 10.1111/aji.13606.

Deficiency in CD4 T Cells Leads to Enhanced Postpartum Internal Carotid Artery Vasoconstriction in Mice: The Role of Nitric Oxide.

Gokina N, Fairchild R, Prakash K, DeLance N, Bonney E Front Physiol. 2021; 12:686429.

PMID: 34220551 PMC: 8242360. DOI: 10.3389/fphys.2021.686429.

The Cellular Transcriptome in the Maternal Circulation During Normal Pregnancy: A Longitudinal Study.

Gomez-Lopez N, Romero R, Hassan S, Bhatti G, Berry S, Kusanovic J Front Immunol. 2020; 10:2863.

PMID: 31921132 PMC: 6928201. DOI: 10.3389/fimmu.2019.02863.

Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone.

Arenas-Hernandez M, Romero R, Xu Y, Panaitescu B, Garcia-Flores V, Miller D J Immunol. 2019; 202(9):2585-2608.

PMID: 30918041 PMC: 6570421. DOI: 10.4049/jimmunol.1801350.

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