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Wilson's Disease: MRI Features

Overview
Journal J Pediatr Neurosci
Specialty Pediatrics
Date 2011 Oct 7
PMID 21977083
Citations 7
Authors
Paramdeep Singh
Archana Ahluwalia
Kavita Saggar
Charanpreet Singh Grewal
Affiliations
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Abstract

A 15-year-old boy presented with coarse tremors of right hand and dysarthric speech. Neurologic examination demonstrated Kayser-Fleischer rings and dystonic tremor of the right hand. Serum ceruloplasmin and urine copper studies established the diagnosis of Wilson's disease. Brain MRI showed bilateral T2 hyperintensity involving putamen, thalami, and brainstem. Involvement of brainstem revealed the characteristic "double panda sign."

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References
1.
Jacobs D, Markowitz C, Liebeskind D, Galetta S . The "double panda sign" in Wilson's disease. Neurology. 2003; 61(7):969. DOI: 10.1212/01.wnl.0000085871.98174.4e. View
2.
Kim T, Kim I, Kim W, Cheon J, Moon S, Kwon J . MR imaging of the brain in Wilson disease of childhood: findings before and after treatment with clinical correlation. AJNR Am J Neuroradiol. 2006; 27(6):1373-8. PMC: 8133926. View
3.
Hitoshi S, Iwata M, Yoshikawa K . Mid-brain pathology of Wilson's disease: MRI analysis of three cases. J Neurol Neurosurg Psychiatry. 1991; 54(7):624-6. PMC: 1014434. DOI: 10.1136/jnnp.54.7.624. View
4.
King A, Walshe J, Kendall B, Chinn R, Paley M, Wilkinson I . Cranial MR imaging in Wilson's disease. AJR Am J Roentgenol. 1996; 167(6):1579-84. DOI: 10.2214/ajr.167.6.8956601. View