Maspin Expression in Epithelial Skin Tumours: an Immunohistochemical Study

Overview

Journal J Cutan Aesthet Surg

Date 2011 Oct 7

PMID 21976902

Citations 4

Authors

Asmaa Gaber Abdou

Alaa Hassan Maraee

Mohamed Abd El-Monaem Shoeib

Amany Mohamed Abo Saida

Affiliations

Soon will be listed here.

Abstract

Background: Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, angiogenesis and induce apoptosis.

Aim: The aim of this work is to investigate maspin expression in cutaneous basal and squamous cell carcinomas by means of immunohistochemistry.

Materials And Methods: This study was carried out on 43 patients, 25 basal cell carcinoma (BCC) and 18 squamous cell carcinoma (SCC) together with ten apparently healthy volunteers as a control group.

Results: There was a significant difference between the malignant and control groups regarding maspin expression since all control cases showed maspin expression compared to 60.5% (26/43) positivity in malignant cases. Maspin positive expression tended to be of higher percentage in SCC (77.8%) compared to BCC (48%) (P = 0.06) and the strong intensity of maspin was also significantly in favour of SCC compared to BCC (P = 0.02). The staining of both the cytoplasm and nuclei was seen in 27.7% of SCC and 12% of BCC and was significantly in favour of older age group (P = 0.02) and the adenoid variant (P = 0.04) of the latter.

Conclusions: Maspin is associated with terminal squamous differentiation. Nuclear staining of maspin is seen in both BCC and SCC with a suggested tumour suppressor role in BCC.

Citing Articles

Maspin impairs the function of endothelial cells: an implying pathway of preeclampsia.

Zhang Y, Liu H, Shi X, Qiao F, Zeng W, Feng L BMC Pregnancy Childbirth. 2017; 17(1):328.

PMID: 28962595 PMC: 5622509. DOI: 10.1186/s12884-017-1525-z.

Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma.

Lupu M, Caruntu C, Ghita M, Voiculescu V, Voiculescu S, Rosca A Dis Markers. 2016; 2016:9831237.

PMID: 27578920 PMC: 4992754. DOI: 10.1155/2016/9831237.

Unexpected maspin immunoreactivity in Merkel cell carcinoma.

Turdean S, Gurzu S, Jung I, Neagoe R, Sala D Diagn Pathol. 2015; 10:206.

PMID: 26607425 PMC: 4660833. DOI: 10.1186/s13000-015-0437-3.

Expression of maspin and ezrin proteins in periocular Basal cell carcinoma.

Bagheri M, Eghtedari M, Bagheri M, Geramizadeh B, Talebnejad M Dermatol Res Pract. 2015; 2014:596564.

PMID: 25580109 PMC: 4279255. DOI: 10.1155/2014/596564.

References

Blandamura S, Giacomelli L, Leo G, Segato P, Ninfo V . Nuclear maspin detection in renal cell tumours: possible diagnostic role and correlation with p53 status. Histopathology. 2006; 49(3):274-82. DOI: 10.1111/j.1365-2559.2006.02504.x. View

KATZ A, Taichman L . A partial catalog of proteins secreted by epidermal keratinocytes in culture. J Invest Dermatol. 1999; 112(5):818-21. DOI: 10.1046/j.1523-1747.1999.00572.x. View

PEMBERTON P, Tipton A, Pavloff N, Smith J, Erickson J, Mouchabeck Z . Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface. J Histochem Cytochem. 1998; 45(12):1697-706. DOI: 10.1177/002215549704501213. View

Zou Z, Anisowicz A, Hendrix M, Thor A, Neveu M, Sheng S . Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science. 1994; 263(5146):526-9. DOI: 10.1126/science.8290962. View

Bayer-Garner I, Smoller B . Androgen receptors: a marker to increase sensitivity for identifying breast cancer in skin metastasis of unknown primary site. Mod Pathol. 2000; 13(2):119-22. DOI: 10.1038/modpathol.3880021. View

Zhang M, Sheng S, Maass N, Sager R . mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility. Mol Med. 1997; 3(1):49-59. PMC: 2230109. View

Bieche I, Girault I, Sabourin J, Tozlu S, Driouch K, Vidaud M . Prognostic value of maspin mRNA expression in ER alpha-positive postmenopausal breast carcinomas. Br J Cancer. 2003; 88(6):863-70. PMC: 2377080. DOI: 10.1038/sj.bjc.6600812. View

Czerwenka K, Manavi M, Hosmann J, Jelincic D, Pischinger K, Battistutti W . Comparative analysis of two-dimensional protein patterns in malignant and normal human breast tissue. Cancer Detect Prev. 2001; 25(3):268-79. View

Cox N . Basal cell carcinoma in young adults. Br J Dermatol. 1992; 127(1):26-9. DOI: 10.1111/j.1365-2133.1992.tb14820.x. View

10.

Lee M, Suh C, Li Z . Clinicopathological significance of maspin expression in breast cancer. J Korean Med Sci. 2006; 21(2):309-14. PMC: 2734010. DOI: 10.3346/jkms.2006.21.2.309. View

11.

Wang M, Yang Y, Li X, Dong F, Li Y . Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer. World J Gastroenterol. 2004; 10(5):634-7. PMC: 4716899. DOI: 10.3748/wjg.v10.i5.634. View

12.

Maass N, Hojo T, Ueding M, Luttges J, Kloppel G, Jonat W . Expression of the tumor suppressor gene Maspin in human pancreatic cancers. Clin Cancer Res. 2001; 7(4):812-7. View

13.

Ngamkitidechakul C, Burke J, OBrien W, Twining S . Maspin: synthesis by human cornea and regulation of in vitro stromal cell adhesion to extracellular matrix. Invest Ophthalmol Vis Sci. 2001; 42(13):3135-41. View

14.

Leffell D, HEADINGTON J, Wong D, Swanson N . Aggressive-growth basal cell carcinoma in young adults. Arch Dermatol. 1991; 127(11):1663-7. View

15.

Joensuu K, Leidenius M, Andersson L, Heikkila P . High expression of maspin is associated with early tumor relapse in breast cancer. Hum Pathol. 2009; 40(8):1143-51. DOI: 10.1016/j.humpath.2009.02.006. View

16.

Kim S, Han J, Kim J, Park C . Maspin expression is transactivated by p63 and is critical for the modulation of lung cancer progression. Cancer Res. 2004; 64(19):6900-5. DOI: 10.1158/0008-5472.CAN-04-1657. View

17.

Khalkhali-Ellis Z . Maspin: the new frontier. Clin Cancer Res. 2006; 12(24):7279-83. PMC: 3175762. DOI: 10.1158/1078-0432.CCR-06-1589. View

18.

Solomon L, Munkarah A, Schimp V, Arabi M, Morris R, Nassar H . Maspin expression and localization impact on angiogenesis and prognosis in ovarian cancer. Gynecol Oncol. 2006; 101(3):385-9. DOI: 10.1016/j.ygyno.2005.11.049. View

19.

Bailey C, Khalkhali-Ellis Z, Seftor E, Hendrix M . Biological functions of maspin. J Cell Physiol. 2006; 209(3):617-24. DOI: 10.1002/jcp.20782. View

20.

Marioni G, Gaio E, Giacomelli L, Bertolin A, DAlessandro E, Stramare R . MASPIN subcellular localization and expression in oral cavity squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2008; 265 Suppl 1:S97-104. DOI: 10.1007/s00405-008-0583-2. View