Mechanisms Pertaining to Arsenic Toxicity

Overview

Journal Toxicol Int

Date 2011 Oct 7

PMID 21976811

Citations 92

Authors

Amrit Pal Singh

Rajesh Kumar Goel

Tajpreet Kaur

Affiliations

Soon will be listed here.

Abstract

Arsenic is an environmental pollutant and its contamination in the drinking water is considered as a serious worldwide environmental health threat. The chronic arsenic exposure is a cause of immense health distress as it accounts for the increased risk of various disorders such as cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. In addition, the exposure to arsenic has been suggested to affect the liver function and to induce hepatotoxicity. Moreover, few studies demonstrated the induction of carcinogenicity especially cancer of the skin, bladder, and lungs after the chronic exposure to arsenic. The present review addresses diverse mechanisms involved in the pathogenesis of arsenic-induced toxicity and end-organ damage.

Citing Articles

Ameliorative and protective effects of coenzyme Q10 against natural and chemical toxicity: a narrative review.

Keshavarzi M, Naraki K, Razavi B, Hosseinzadeh H Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 40080152 DOI: 10.1007/s00210-025-03992-5.

Review on the impact of heavy metals from industrial wastewater effluent and removal technologies.

Oladimeji T, Oyedemi M, Emetere M, Agboola O, Adeoye J, Odunlami O Heliyon. 2024; 10(23):e40370.

PMID: 39654720 PMC: 11625160. DOI: 10.1016/j.heliyon.2024.e40370.

Heavy metals: toxicity and human health effects.

Jomova K, Alomar S, Nepovimova E, Kuca K, Valko M Arch Toxicol. 2024; 99(1):153-209.

PMID: 39567405 PMC: 11742009. DOI: 10.1007/s00204-024-03903-2.

Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity.

Nguyen C, Alvarado M, Huh W, Batisti J Clin J Gastroenterol. 2024; 18(1):114-118.

PMID: 39377877 DOI: 10.1007/s12328-024-02045-3.

Unveiling the link between arsenic toxicity and diabetes: an in silico exploration into the role of transcription factors.

Fatema K, Haidar Z, Tanim M, Nath S, Sajib A Toxicol Res. 2024; 40(4):653-672.

PMID: 39345741 PMC: 11436564. DOI: 10.1007/s43188-024-00255-y.

References

Alam M, Allinson G, Stagnitti F, Tanaka A, Westbrooke M . Arsenic contamination in Bangladesh groundwater: a major environmental and social disaster. Int J Environ Health Res. 2002; 12(3):235-53. DOI: 10.1080/0960312021000000998. View

Rodriguez V, Carrizales L, Mendoza M, Fajardo O, Giordano M . Effects of sodium arsenite exposure on development and behavior in the rat. Neurotoxicol Teratol. 2002; 24(6):743-50. DOI: 10.1016/s0892-0362(02)00313-6. View

Tsai S, Hsieh M, Chen L, Liang Y, Lin J, Lin S . Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species. Toxicol Lett. 2001; 123(1):11-9. DOI: 10.1016/s0378-4274(01)00373-3. View

Li G, Pei Q, Gao Y, Liu K, Nie J, Han G . Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats. Exp Toxicol Pathol. 2007; 58(6):447-53. DOI: 10.1016/j.etp.2007.02.001. View

Kokilavani V, Devi M, Sivarajan K, Panneerselvam C . Combined efficacies of DL-alpha-lipoic acid and meso 2,3 dimercaptosuccinic acid against arsenic induced toxicity in antioxidant systems of rats. Toxicol Lett. 2005; 160(1):1-7. DOI: 10.1016/j.toxlet.2005.05.018. View

Pysher M, Chen Q, Vaillancourt R . Arsenic alters vascular smooth muscle cell focal adhesion complexes leading to activation of FAK-src mediated pathways. Toxicol Appl Pharmacol. 2008; 231(2):135-41. PMC: 3900024. DOI: 10.1016/j.taap.2008.04.002. View

Lee M, Lee Y, Lim K, Chung S, Bae O, Kim H . Inorganic arsenite potentiates vasoconstriction through calcium sensitization in vascular smooth muscle. Environ Health Perspect. 2005; 113(10):1330-5. PMC: 1281275. DOI: 10.1289/ehp.8000. View

Sasaki A, Oshima Y, Fujimura A . An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007; 35(2):252-62. DOI: 10.1016/j.exphem.2006.10.004. View

Burton C, Hatlelid K, Divine K, Carter D, Fernando Q, Brendel K . Glutathione effects on toxicity and uptake of mercuric chloride and sodium arsenite in rabbit renal cortical slices. Environ Health Perspect. 1995; 103 Suppl 1:81-4. PMC: 1519341. DOI: 10.1289/ehp.95103s181. View

10.

Chen Y, Parvez F, Gamble M, Islam T, Ahmed A, Argos M . Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study.... Toxicol Appl Pharmacol. 2009; 239(2):184-92. PMC: 3904798. DOI: 10.1016/j.taap.2009.01.010. View

11.

Dwivedi N, Flora S . Concomitant exposure to arsenic and organophosphates on tissue oxidative stress in rats. Food Chem Toxicol. 2011; 49(5):1152-9. DOI: 10.1016/j.fct.2011.02.007. View

12.

Wauson E, Langan A, Vorce R . Sodium arsenite inhibits and reverses expression of adipogenic and fat cell-specific genes during in vitro adipogenesis. Toxicol Sci. 2002; 65(2):211-9. DOI: 10.1093/toxsci/65.2.211. View

13.

Kruger K, Straub H, Hirner A, Hippler J, Binding N, Musshoff U . Effects of monomethylarsonic and monomethylarsonous acid on evoked synaptic potentials in hippocampal slices of adult and young rats. Toxicol Appl Pharmacol. 2009; 236(1):115-23. DOI: 10.1016/j.taap.2008.12.025. View

14.

Diaz-Villasenor A, Sanchez-Soto M, Cebrian M, Ostrosky-Wegman P, Hiriart M . Sodium arsenite impairs insulin secretion and transcription in pancreatic beta-cells. Toxicol Appl Pharmacol. 2006; 214(1):30-4. DOI: 10.1016/j.taap.2005.11.015. View

15.

Simeonova P, Wang S, Toriuma W, Kommineni V, Matheson J, Unimye N . Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res. 2000; 60(13):3445-53. View

16.

Izquierdo-Vega J, Soto C, Sanchez-Pena L, De Vizcaya-Ruiz A, Del Razo L . Diabetogenic effects and pancreatic oxidative damage in rats subchronically exposed to arsenite. Toxicol Lett. 2005; 160(2):135-42. DOI: 10.1016/j.toxlet.2005.06.018. View

17.

Lee P, Ho I, Lee T . Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. Toxicol Sci. 2005; 85(1):541-50. DOI: 10.1093/toxsci/kfi101. View

18.

Yip S, Yeung Y . Severe neurotoxicity following arsenic therapy for acute promyelocytic leukemia: potentiation by thiamine deficiency. Blood. 2002; 99(9):3481-2. DOI: 10.1182/blood-2001-12-0325. View

19.

Das A, Bag S, Sahu R, Dua T, Sinha M, Gangopadhyay M . Protective effect of Corchorus olitorius leaves on sodium arsenite-induced toxicity in experimental rats. Food Chem Toxicol. 2009; 48(1):326-35. DOI: 10.1016/j.fct.2009.10.020. View

20.

Jindal S, Singh M, Balakumar P . Effect of bis (maltolato) oxovanadium (BMOV) in uric acid and sodium arsenite-induced vascular endothelial dysfunction in rats. Int J Cardiol. 2007; 128(3):383-91. DOI: 10.1016/j.ijcard.2007.05.031. View