Early Generalized Overgrowth in Boys with Autism

Overview

Journal Arch Gen Psychiatry

Specialty Psychiatry

Date 2011 Oct 5

PMID 21969460

Citations 48

Authors

Katarzyna Chawarska

Daniel Campbell

Lisha Chen

Frederick Shic

Ami Klin

Joseph Chang

Affiliations

Soon will be listed here.

Abstract

Context: Multiple studies have reported an overgrowth in head circumference (HC) in the first year of life in autism. However, it is unclear whether this phenomenon is independent of overall body growth and whether it is associated with specific social or cognitive features.

Objectives: To examine the trajectory of early HC growth in autism compared with control groups; to assess whether HC growth in autism is independent of height and weight growth during infancy; and to examine HC growth from birth to 24 months in relationship to social, verbal, cognitive, and adaptive functioning levels.

Design: Retrospective study.

Setting: A specialized university-based clinic.

Participants: Boys diagnosed as having autistic disorder (n = 64), pervasive developmental disorder-not otherwise specified (n = 34), global developmental delay (n = 13), and other developmental problems (n = 18) and typically developing boys (n = 55).

Main Outcome Measures: Age-related changes in HC, height, and weight between birth and age 24 months; measures of social, verbal, and cognitive functioning at age 2 years.

Results: Compared with typically developing controls, boys with autism were significantly longer by age 4.8 months, had a larger HC by age 9.5 months, and weighed more by age 11.4 months (P = .05 for all). None of the other clinical groups showed a similar overgrowth pattern. Boys with autism who were in the top 10% of overall physical size in infancy exhibited greater severity of social deficits (P = .009) and lower adaptive functioning (P = .03).

Conclusions: Boys with autism experienced accelerated HC growth in the first year of life. However, this phenomenon reflected a generalized process affecting other morphologic features, including height and weight. The study highlights the importance of studying factors that influence not only neuronal development but also skeletal growth in autism.

Citing Articles

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References

Tsai S . Is autism caused by early hyperactivity of brain-derived neurotrophic factor?. Med Hypotheses. 2005; 65(1):79-82. DOI: 10.1016/j.mehy.2005.01.034. View

Lauder J . Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Ann N Y Acad Sci. 1990; 600:297-313; discussion 314. DOI: 10.1111/j.1749-6632.1990.tb16891.x. View

Gerber H, Hillan K, Ryan A, Kowalski J, Keller G, RANGELL L . VEGF is required for growth and survival in neonatal mice. Development. 1999; 126(6):1149-59. DOI: 10.1242/dev.126.6.1149. View

Courchesne E, Carper R, Akshoomoff N . Evidence of brain overgrowth in the first year of life in autism. JAMA. 2003; 290(3):337-44. DOI: 10.1001/jama.290.3.337. View

Varga E, Pastore M, Prior T, Herman G, McBride K . The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly. Genet Med. 2009; 11(2):111-7. DOI: 10.1097/GIM.0b013e31818fd762. View

Mills J, Hediger M, Molloy C, Chrousos G, Manning-Courtney P, Yu K . Elevated levels of growth-related hormones in autism and autism spectrum disorder. Clin Endocrinol (Oxf). 2007; 67(2):230-7. DOI: 10.1111/j.1365-2265.2007.02868.x. View

Fombonne E, Roge B, Claverie J, Courty S, Fremolle J . Microcephaly and macrocephaly in autism. J Autism Dev Disord. 1999; 29(2):113-9. DOI: 10.1023/a:1023036509476. View

Geschwind D, Levitt P . Autism spectrum disorders: developmental disconnection syndromes. Curr Opin Neurobiol. 2007; 17(1):103-11. DOI: 10.1016/j.conb.2007.01.009. View

Butler M, Dasouki M, Zhou X, Talebizadeh Z, Brown M, Takahashi T . Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet. 2005; 42(4):318-21. PMC: 1736032. DOI: 10.1136/jmg.2004.024646. View

10.

Vaccarino F, Smith K . Increased brain size in autism--what it will take to solve a mystery. Biol Psychiatry. 2009; 66(4):313-5. PMC: 2803090. DOI: 10.1016/j.biopsych.2009.06.013. View

11.

Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R . Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol. 2001; 15(10):1748-57. DOI: 10.1210/mend.15.10.0706. View

12.

Davidovitch M, Patterson B, Gartside P . Head circumference measurements in children with autism. J Child Neurol. 1996; 11(5):389-93. DOI: 10.1177/088307389601100509. View

13.

Fukumoto A, Hashimoto T, Ito H, Nishimura M, Tsuda Y, Miyazaki M . Growth of head circumference in autistic infants during the first year of life. J Autism Dev Disord. 2007; 38(3):411-8. DOI: 10.1007/s10803-007-0405-1. View

14.

Chawarska K, Klin A, Paul R, Macari S, Volkmar F . A prospective study of toddlers with ASD: short-term diagnostic and cognitive outcomes. J Child Psychol Psychiatry. 2009; 50(10):1235-45. PMC: 4878113. DOI: 10.1111/j.1469-7610.2009.02101.x. View

15.

Redcay E, Courchesne E . When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol Psychiatry. 2005; 58(1):1-9. DOI: 10.1016/j.biopsych.2005.03.026. View

16.

Miyazaki K, Narita N, Sakuta R, Miyahara T, Naruse H, Okado N . Serum neurotrophin concentrations in autism and mental retardation: a pilot study. Brain Dev. 2004; 26(5):292-5. DOI: 10.1016/S0387-7604(03)00168-2. View

17.

Lord C, Risi S, Lambrecht L, Cook Jr E, Leventhal B, DiLavore P . The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord. 2000; 30(3):205-23. View

18.

Connolly A, Chez M, Streif E, Keeling R, Golumbek P, Kwon J . Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. Biol Psychiatry. 2005; 59(4):354-63. DOI: 10.1016/j.biopsych.2005.07.004. View

19.

KANNER L . Autistic disturbances of affective contact. Acta Paedopsychiatr. 1968; 35(4):100-36. View

20.

Lotspeich L, Kwon H, Schumann C, Fryer S, Goodlin-Jones B, Buonocore M . Investigation of neuroanatomical differences between autism and Asperger syndrome. Arch Gen Psychiatry. 2004; 61(3):291-8. DOI: 10.1001/archpsyc.61.3.291. View