Spatial Frequency Threshold and Contrast Sensitivity of an Optomotor Behavior Are Impaired in the Ins2Akita Mouse Model of Diabetes

Overview

Journal Behav Brain Res

Specialties Neurology
Psychology
Social Sciences

Date 2011 Oct 4

PMID 21963766

Citations 24

Authors

Nikolay P Akimov

Rene C Renteria

Affiliations

Soon will be listed here.

Abstract

Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2(Akita) mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we show that Ins2(Akita) mice have progressive, quantifiable vision deficits in an optomotor behavior. This mouse line is a promising model in which to understand the contribution of retinal neuronal injury during the chronic hyperglycemia and hypoinsulinemia of diabetes to deficits in vision.

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