Monocytes Link Atherosclerosis and Cancer

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 2011 Sep 29

PMID 21952809

Citations 20

Authors

Mikael J Pittet

Filip K Swirski

Affiliations

Soon will be listed here.

Abstract

From many perspectives, cardiovascular diseases and cancers are fundamentally different. On the one hand, atherosclerosis is a disease of lipid accumulation driven by diet and lifestyle, whereas cancer is an attack "from within" driven by mutations. Nevertheless, studies over the past 20 years have forced us to re-evaluate such a view. We are learning that, among other factors, the immune system is indispensable for the development and progression of both diseases. Its components are not only reactive but can also orchestrate both tumor and atherosclerotic lesion growth. In this Viewpoint, we explore how monocytes, which are key constituents of the immune system, forge links between cardiovascular diseases and cancers.

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