Dopaminergic Challenge with Bromocriptine One Month After Mild Traumatic Brain Injury: Altered Working Memory and BOLD Response

Overview

Journal J Neuropsychiatry Clin Neurosci

Specialties Neurology
Psychiatry

Date 2011 Sep 28

PMID 21948888

Citations 24

Authors

Thomas W McAllister

Laura A Flashman

Brenna C McDonald

Richard B Ferrell

Tor D Tosteson

Norman N Yanofsky

Margaret R Grove

Andrew J Saykin

Affiliations

Soon will be listed here.

Abstract

Catecholamines, particularly dopamine, modulate working memory (WM). Altered sensitivity to dopamine might play a role in WM changes observed after traumatic brain injury (TBI). Thirty-one healthy controls (HC) and 26 individuals with mild TBI (MTBI) 1 month after injury were challenged with bromocriptine versus placebo before administration of a verbal WM functional MRI task. Bromocriptine was associated with improved WM performance in the HC but not the MTBI group. On bromocriptine, the MTBI group showed increased activation outside of a task-specific region of interest. Findings are consistent with the hypothesis that individuals with MTBI have altered responsivity to dopamine.

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