The Role of Lipoprotein Receptors on the Physiological Function of APP

Overview

Journal Exp Brain Res

Specialty Neurology

Date 2011 Sep 28

PMID 21947084

Citations 13

Authors

Timo Wagner

Claus U Pietrzik

Affiliations

Soon will be listed here.

Abstract

In this review, we will primarily focus on the role of members of the low-density lipoprotein receptor (LDL-R) family that are involved in trafficking and processing of the amyloid precursor protein (APP). We will discuss the role of the LDL-receptor family members, low-density lipoprotein receptor-related protein 1 (LRP1), LRP1b, apolipoprotein E receptor 2, sortilin-related receptor (SorLA/LR11) and megalin/LRP2 on the physiological function of APP and its cellular localization. Additionally, we will focus on adaptor proteins that have been shown to influence the physiological function of LDL-R family members in combination with APP processing. The results in this review emphasize that the physiological function of APP cannot be explained by the focus on the APP protein alone but rather in combination with various direct or indirect interaction partners within the cellular environment.

Citing Articles

Identification and Characterization of the Very-Low-Density Lipoprotein Receptor Gene from : Insights into the Origin and Evolution of the Low-Density Lipoprotein Receptor Gene Family.

Cao Y, Wang H, Jin P, Ma F, Zhou X Animals (Basel). 2023; 13(13).

PMID: 37443991 PMC: 10339998. DOI: 10.3390/ani13132193.

Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.

Eggert S, Thomas C, Kins S, Hermey G Mol Neurobiol. 2017; 55(7):5809-5829.

PMID: 29079999 DOI: 10.1007/s12035-017-0806-x.

Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

Eggert S, Gonzalez A, Thomas C, Schilling S, Schwarz S, Tischer C Cell Mol Life Sci. 2017; 75(2):301-322.

PMID: 28799085 PMC: 11105302. DOI: 10.1007/s00018-017-2625-7.

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.

Steffen J, Krohn M, Schwitlick C, Bruning T, Paarmann K, Pietrzik C Acta Neuropathol Commun. 2017; 5(1):49.

PMID: 28637503 PMC: 5480119. DOI: 10.1186/s40478-017-0448-2.

Functional Roles of the Interaction of APP and Lipoprotein Receptors.

Pohlkamp T, Wasser C, Herz J Front Mol Neurosci. 2017; 10:54.

PMID: 28298885 PMC: 5331069. DOI: 10.3389/fnmol.2017.00054.

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