Mitochondrial Adenine Nucleotide Transport and Cardioprotection

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2011 Sep 28

PMID 21945520

Citations 8

Authors

Samarjit Das

Charles Steenbergen

Affiliations

Soon will be listed here.

Abstract

Mitochondria are highly metabolically active cell organelles that not only act as the powerhouse of the cell by supplying energy through ATP production, but also play a destructive role by initiating cell death pathways. Growing evidence recognizes that mitochondrial dysfunction is one of the major causes of cardiovascular disease. Under de-energized conditions, slowing of adenine nucleotide transport in and out of the mitochondria significantly attenuates myocardial ischemia-reperfusion injury. The purpose of this review is to elaborate on and update the mechanistic pathways which may explain how altered adenine nucleotide transport can influence cardiovascular function. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

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