A Therapeutic Approach for Wound Healing by Using Essential Oils of Cupressus and Juniperus Species Growing in Turkey

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2011 Sep 24

PMID 21941588

Citations 15

Authors

Ibrahim Tumen

Ipek Suntar

Hikmet Keles

Esra Kupeli Akkol

Affiliations

Soon will be listed here.

Abstract

Juniperus and Cupressus genera are mainly used as diuretic, stimulant, and antiseptic, for common cold and wound healing in Turkish folk medicine. In the present study, essential oils obtained from cones of Cupressus and berries of Juniperus were evaluated for their wound healing and anti-inflammatory effects. In vivo wound healing activity was evaluated by linear incision and circular excision experimental wound models, assessment of hydroxyproline content, and subsequently histopathological analysis. The healing potential was comparatively assessed with a reference ointment Madecassol. Additionally acetic-acid-induced capillary permeability test was used for the oils' anti-inflammatory activity. The essential oils of J. oxycedrus subsp. oxycedrus and J. phoenicea demonstrated the highest activities, while the rest of the species did not show any significant wound healing effect. The experimental study revealed that J. oxycedrus subsp. oxycedrus and J. phoenicea display remarkable wound healing and anti-inflammatory activities, which support the folkloric use of the plants.

Citing Articles

recovers disturbance of normal male fertilization in -infected mice.

Koriem K, El-Gohary T J Parasit Dis. 2025; 49(1):149-161.

PMID: 39975607 PMC: 11832875. DOI: 10.1007/s12639-024-01730-x.

Chemodiversity and Bioactivity of the Essential Oils of and Implication for Taxonomy.

Hu H, Li D, Bai R, Zhang W, Luo H, Yu E Int J Mol Sci. 2023; 24(20).

PMID: 37894884 PMC: 10607841. DOI: 10.3390/ijms242015203.

Volatiles of All Native Species Growing in Greece-Antimicrobial Properties.

Fotiadou E, Panou E, Graikou K, Sakellarakis F, Chinou I Foods. 2023; 12(18).

PMID: 37761215 PMC: 10530231. DOI: 10.3390/foods12183506.

Biological Activity of Essential oil and the Roles of Its Chemical Components in the Wound Healing Process.

Espinosa-Espinosa L, Canales-Alvarez O, Rodriguez-Lopez M, Flores-Tinajero C, Canales-Martinez M, Rodriguez-Monroy M Int J Mol Sci. 2023; 24(13).

PMID: 37446220 PMC: 10341907. DOI: 10.3390/ijms241311040.

A Status Review on Health-Promoting Properties and Global Regulation of Essential Oils.

Osaili T, Dhanasekaran D, Zeb F, Faris M, Naja F, Radwan H Molecules. 2023; 28(4).

PMID: 36838797 PMC: 9968027. DOI: 10.3390/molecules28041809.

References

Lodhi S, Pawar R, Jain A, Singhai A . Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats. J Ethnopharmacol. 2006; 108(2):204-10. DOI: 10.1016/j.jep.2006.05.011. View

Shetty B, Udupa S, Udupa A, Somayaji S . Effect of Centella asiatica L (Umbelliferae) on normal and dexamethasone-suppressed wound healing in Wistar Albino rats. Int J Low Extrem Wounds. 2006; 5(3):137-43. DOI: 10.1177/1534734606291313. View

Sadaf F, Saleem R, Ahmed M, Ahmad S, Navaid-ul-Zafar . Healing potential of cream containing extract of Sphaeranthus indicus on dermal wounds in Guinea pigs. J Ethnopharmacol. 2006; 107(2):161-3. DOI: 10.1016/j.jep.2006.02.022. View

Suguna L, Singh S, Sivakumar P, Sampath P, Chandrakasan G . Influence of Terminalia chebula on dermal wound healing in rats. Phytother Res. 2002; 16(3):227-31. DOI: 10.1002/ptr.827. View

Topcu G, Erenler R, Cakmak O, Johansson C, Celik C, Chai H . Diterpenes from the berries of Juniperus excelsa. Phytochemistry. 1999; 50(7):1195-9. DOI: 10.1016/s0031-9422(98)00675-x. View

Gadek P, Alpers D, Heslewood M, Quinn C . Relationships within Cupressaceae sensu lato: a combined morphological and molecular approach. Am J Bot. 2000; 87(7):1044-57. View

WHITTLE B . THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ALALGESICS. Br J Pharmacol Chemother. 1964; 22:246-53. PMC: 1703970. DOI: 10.1111/j.1476-5381.1964.tb02030.x. View

Yesilada E, Kupeli E . Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects. J Ethnopharmacol. 2006; 110(3):504-15. DOI: 10.1016/j.jep.2006.10.016. View

Orhan I, Kupeli E, Aslan M, Kartal M, Yesilada E . Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L. J Ethnopharmacol. 2005; 105(1-2):235-40. DOI: 10.1016/j.jep.2005.10.023. View

10.

Rasik A, Raghubir R, Gupta A, Shukla A, Dubey M, Srivastava S . Healing potential of Calotropis procera on dermal wounds in Guinea pigs. J Ethnopharmacol. 2000; 68(1-3):261-6. DOI: 10.1016/s0378-8741(99)00118-x. View

11.

Yesilada E, Sezik E, Honda G, Takaishi Y, Takeda Y, Tanaka T . Traditional medicine in Turkey IX: folk medicine in north-west Anatolia. J Ethnopharmacol. 1999; 64(3):195-210. DOI: 10.1016/s0378-8741(98)00133-0. View

12.

Woessner Jr J . The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys. 1961; 93:440-7. DOI: 10.1016/0003-9861(61)90291-0. View

13.

Stanley P, Steiner S, Havens M, Tramposch K . Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate. Skin Pharmacol. 1991; 4(4):262-71. DOI: 10.1159/000210960. View

14.

Suntar I, Koca U, Keles H, Akkol E . Wound Healing Activity of Rubus sanctus Schreber (Rosaceae): Preclinical Study in Animal Models. Evid Based Complement Alternat Med. 2009; 2011:816156. PMC: 3139958. DOI: 10.1093/ecam/nep137. View

15.

Ozturk M, Tumen I, Ugur A, Aydogmus-Ozturk F, Topcu G . Evaluation of fruit extracts of six Turkish Juniperus species for their antioxidant, anticholinesterase and antimicrobial activities. J Sci Food Agric. 2011; 91(5):867-76. DOI: 10.1002/jsfa.4258. View