Interaction of Lipid Transfer Protein with Plasma Lipoproteins and Cell Membranes

Overview

Journal Experientia

Specialty Science

Date 1990 Jun 15

PMID 2193818

Citations 17

Authors

R E MORTON

Affiliations

Soon will be listed here.

Abstract

The hydrophobic lipid components of lipoproteins, cholesteryl ester and triglyceride, are transferred between all lipoproteins by a specific plasma glycoprotein, termed lipid transfer protein (LTP). LTP facilitates lipid transfer by an exchange process in which cholesteryl ester and triglyceride compete for transfer. Thus, LTP promotes remodeling of the lipoprotein structure, and plays an important role in the intravascular metabolism of these particles and in the lipoprotein-dependent pathways of cholesterol clearance from cells. The properties of LTP, its mechanisms of action, its roles in lipoprotein metabolism, and its modes of regulation are reviewed along with recent data that suggest a possible role for this protein in directly modifying cellular lipid composition.

Citing Articles

Both full length-cholesteryl ester transfer protein and exon 9-deleted cholesteryl ester transfer protein promote triacylglycerol storage in cultured hepatocytes.

Liu Y, Mihna D, Izem L, Morton R Lipids. 2021; 57(1):69-79.

PMID: 34866179 PMC: 9060302. DOI: 10.1002/lipd.12330.

Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage.

Izem L, Liu Y, Morton R J Lipid Res. 2020; 61(3):422-431.

PMID: 31988147 PMC: 7053842. DOI: 10.1194/jlr.RA120000583.

Emerging risk biomarkers in cardiovascular diseases and disorders.

Upadhyay R J Lipids. 2015; 2015:971453.

PMID: 25949827 PMC: 4407625. DOI: 10.1155/2015/971453.

Modification of CETP function by changing its substrate preference: a new paradigm for CETP drug design.

Morton R, Izem L J Lipid Res. 2015; 56(3):612-619.

PMID: 25616437 PMC: 4340308. DOI: 10.1194/jlr.M056333.

Conversion of lipid transfer inhibitor protein (apolipoprotein F) to its active form depends on LDL composition.

Morton R, Greene D J Lipid Res. 2011; 52(12):2262-2271.

PMID: 21937674 PMC: 3220293. DOI: 10.1194/jlr.M018283.

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