Direct and Selective Binding of an Acidic Transcriptional Activation Domain to the TATA-box Factor TFIID

Overview

Journal Nature

Specialty Science

Date 1990 Jun 28

PMID 2193231

Citations 275

Authors

K F Stringer

C J Ingles

J GREENBLATT

Affiliations

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Abstract

The potent transactivation domain of the herpes simplex virion protein VP16 was used as a column ligand for affinity chromatography. VP16 binds strongly and highly selectively to the human and yeast TATA box-binding factors. Our results imply that the principal target for acidic activation domains is the TATA-box factor TFIID.

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