TRPM Channels: Same Ballpark, Different Players, and Different Rules in Immunogenetics

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 2011 Sep 21

PMID 21932052

Citations 14

Authors

Ammad Ahmad Farooqi

Mohammed Khalid Javeed

Zeeshan Javed

Asma M Riaz

Shahzeray Mukhtar

Sehrish Minhaj

Sana Abbas

Shahzad Bhatti

Affiliations

Soon will be listed here.

Abstract

Transient receptor potential (TRP) channels belong to a large family of cation channels and are the "border guards" predominantly localized to the plasma membrane. Research over the years has considerably and highly developed the knowledge of expression and functional aspects of the TRPM channels. A closer look at the channel dynamics has dismantled undeniable substantiation for multifaceted roles for TRPM channel-mediated extracellular Ca(2+) influx in several physiological and pathophysiological functions. Given the wealth of literature unfolding the multiple roles of TRP channels in physiology in a very extensive range of different mammalian tissues, this review confines itself to the literature describing the multiple roles of TRPM channels in diabetes, smooth muscle cell regulation, immunological responses, and emerging aspects of cancer. We also focus on differential activities of TRPM channels after post-transcriptional and post-translational processing and their exquisite roles at various cellular and molecular levels.

Citing Articles

Ion Channel Genes in Painful Neuropathies.

Sleczkowska M, Misra K, Santoro S, Gerrits M, Hoeijmakers J Biomedicines. 2023; 11(10).

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Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.

Kamali F, Jamee M, Sayer J, Sadeghi-Bojd S, Golchehre Z, Dehghanzad R CEN Case Rep. 2023; 12(4):413-418.

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RAGE Regulating Vascular Remodeling in Diabetes by Regulating Mitochondrial Dynamics with JAK2/STAT3 Pathway.

Sun S, Chen Q, Wu B, Huang Q, Maimaitijiang A Comput Intell Neurosci. 2022; 2022:2685648.

PMID: 35498181 PMC: 9054424. DOI: 10.1155/2022/2685648.

A Chinese patient with developmental and epileptic encephalopathies (DEE) carrying a TRPM3 gene mutation: a paediatric case report.

Kang Q, Yang L, Liao H, Yang S, Kuang X, Ning Z BMC Pediatr. 2021; 21(1):256.

PMID: 34074259 PMC: 8167971. DOI: 10.1186/s12887-021-02719-8.

Transient receptor potential (TRP) channels in human colorectal cancer: evidence and perspectives.

Rizopoulos T, Assimakopoulou M Histol Histopathol. 2021; 36(5):515-526.

PMID: 33528023 DOI: 10.14670/HH-18-308.

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